https://transhumanist.ru/index.php?action=history&feed=atom&title=TRIM27 2026-06-23T08:55:37Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TRIM27&diff=4607&oldid=prev 2021-04-29T19:26:12Z

<p>Новая страница: «Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing prote...»</p> <p><b>Новая страница</b></p><div>Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27) [RFP] [RNF76]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[TRIM27]] Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251042<br /> |abstract=In the current study, we aimed to explore the correlation between [[TRIM27]] and breast cancer prognosis, as well as the functions of [[TRIM27]] in breast cancer and their underlying mechanisms. Bioinformatics analyses were used to examine the correlation between [[TRIM27]] and breast cancer prognosis. Moreover, [[TRIM27]] knockdown and overexpression in breast cancer cells were performed to investigate its functions in breast cancer. Tamoxifen (TAM) was applied to evaluate the influence of [[TRIM27]] on chemoresistance of breast cancer cells, while co-immunoprecipitation (coIP) was performed to identify the E3 ubiquitin ligase capability of [[TRIM27]]. High expression of [[TRIM27]] was found in non-triple-negative breast cancer (non-TNBC) tumor tissues and was positively correlated with the mortality of non-TNBC patients. Moreover, [[TRIM27]] could suppress non-TNBC cell apoptosis and senescence, promote cell viability and tumor growth, counteract the anti-cancer effects of TAM, and mediate ubiquitination of p21. In addition, [[EP300]] could enhance the expression of [[TRIM27]] and its transcription promoter H3K27ac. [[TRIM27]], through ubiquitination of p21, might serve as a prognostic biomarker for non-TNBC prognosis. [[TRIM27]] functions as a novel oncogene in non-TNBC cellular processes, especially suppressing cell senescence and interfering with non-TNBC chemoresistance.<br /> <br /> |keywords=* EP300<br /> * TRIM27<br /> * breast cancer<br /> * cell apoptosis<br /> * cell senescence<br /> * chemoresistance<br /> * p21<br /> * prognosis<br /> * transcription<br /> * ubiquitination<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666371<br /> }}</div>

OdysseusBot