https://transhumanist.ru/index.php?action=history&feed=atom&title=TNK1TNK1 - История изменений2026-04-13T15:40:51ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=TNK1&diff=4546&oldid=prevOdysseusBot: Новая страница: «Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) ==Publications== {{medline-entry |title=Role of CLU, PICALM, and TNK1...»2021-04-29T19:23:14Z<p>Новая страница: «Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) ==Publications== {{medline-entry |title=Role of <a href="/CLU" title="CLU">CLU</a>, <a href="/PICALM" title="PICALM">PICALM</a>, and TNK1...»</p>
<p><b>Новая страница</b></p><div>Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Role of [[CLU]], [[PICALM]], and [[TNK1]] Genotypes in Aging With and Without Alzheimer's Disease.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28631188<br />
|abstract=Healthy and impaired cognitive aging may be associated to different prevalences of single-nucleotide polymorphisms (SNPs). In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, [[CLU]]), rs541458 (phosphatidylinositol binding clatrin assembly protein, [[PICALM]]), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, [[TNK1]]) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80 years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients. In NoCI subjects, a regression analysis suggested a relationship between age and [[TNK1]] genotypes, with the [[TNK1]]-A/A genotype frequency that increased with higher age, and resulting in a different distribution of the [[TNK1]]-A allele. In AD patients, a regression analysis suggested a relationship between age and [[PICALM]] genotypes and [[TNK1]] genotypes, with the [[PICALM]]-T/C and [[TNK1]]-A/A genotype frequencies that decreased with increasing age. A resulting difference in the distribution of [[PICALM]]-C allele and [[TNK1]]-A allele was also observed. The [[TNK1]]-A allele was overrepresented in NoCI subjects than in AD patients in age groups 2 and 3. These results confirmed after adjustment for apolipoprotein E polymorphism, which suggested a different role of [[PICALM]] and [[TNK1]] in healthy and impaired cognitive aging. More studies, however, are needed to confirm the observed associations.<br />
|mesh-terms=* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Alleles<br />
* Alzheimer Disease<br />
* Clusterin<br />
* Cohort Studies<br />
* Female<br />
* Fetal Proteins<br />
* Gene Frequency<br />
* Genetic Predisposition to Disease<br />
* Humans<br />
* Male<br />
* Middle Aged<br />
* Monomeric Clathrin Assembly Proteins<br />
* Polymorphism, Single Nucleotide<br />
* Protein-Tyrosine Kinases<br />
|keywords=* Alzheimer’s disease<br />
* Biogerontology<br />
* Brain aging<br />
* Cognition<br />
* Dementia<br />
* Genetics<br />
|full-text-url=https://sci-hub.do/10.1007/s12035-017-0547-x<br />
}}</div>OdysseusBot