https://transhumanist.ru/index.php?action=history&feed=atom&title=TMPRSS11A 2026-11-08T19:16:49Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TMPRSS11A&diff=5388&oldid=prev 2021-05-12T13:41:50Z

<p>Новая страница: «Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibili...»</p> <p><b>Новая страница</b></p><div>Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein) [ECRG1] [HATL1] [HESP]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Expression and genetic loss of function analysis of the HAT/DESC cluster proteases [[TMPRSS11A]] and HAT.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21853097<br /> |abstract=Genome mining at the turn of the millennium uncovered a new family of type II transmembrane serine proteases (TTSPs) that comprises 17 members in humans and 19 in mice. TTSPs phylogenetically belong to one of four subfamilies: matriptase, hepsin/TMPRSS, corin and HAT/DESC. Whereas a wealth of information now has been gathered as to the physiological functions of members of the hepsin/TMPRSS, matriptase, and corin subfamilies of TTSPs, comparatively little is known about the functions of the HAT/DESC subfamily of proteases. Here we perform a combined expression and functional analysis of this TTSP subfamily. We show that the five human and seven murine HAT/DESC proteases are coordinately expressed, suggesting a level of functional redundancy. We also perform a comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, [[TMPRSS11A]] and HAT, and show that the two proteases are dispensable for development, health, and long-term survival in the absence of external challenges or additional genetic deficits. Our comprehensive expression analysis and generation of [[TMPRSS11A]]- and HAT-deficient mutant mouse strains provide a valuable resource for the scientific community for further exploration of the HAT/DESC subfamily proteases in physiological and pathological processes.<br /> |mesh-terms=* Aging<br /> * Amino Acid Sequence<br /> * Animals<br /> * Base Sequence<br /> * Gene Expression Profiling<br /> * Gene Expression Regulation, Enzymologic<br /> * Growth and Development<br /> * Health<br /> * Humans<br /> * Membrane Proteins<br /> * Mice<br /> * Molecular Sequence Data<br /> * Multigene Family<br /> * Organ Specificity<br /> * RNA, Messenger<br /> * Serine Endopeptidases<br /> * Serine Proteases<br /> * Survival Analysis<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154331<br /> }}</div>

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