https://transhumanist.ru/index.php?action=history&feed=atom&title=TMEM51 2026-04-16T19:28:05Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TMEM51&diff=4062&oldid=prev 2021-04-29T18:58:36Z

<p>Новая страница: «protein 51 [C1orf72] ==Publications== {{medline-entry |title=Genome-wide analysis of DNA methylation profiles in a senescence-accelerated mouse prone 8 brain us...»</p> <p><b>Новая страница</b></p><div>protein 51 [C1orf72]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Genome-wide analysis of DNA methylation profiles in a senescence-accelerated mouse prone 8 brain using whole-genome bisulfite sequencing.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28130229<br /> |abstract=The pathogenesis of AD is complex and contributed by both genetic and environmental factors. Recent work revealed a potential link between DNA methylation and AD. However, a genome-wide study to identify potential DNA methylation sites involved in AD is still at an early stage. WGBS, an up-to-date technology, was used in this study. We investigated mouse brain genome-wide DNA methylation profiles between seven-month-old SAMP8 and SAMR1 models through deep WGBS. According to the results, the global ML slightly decreased in the SAMP8 mice than in the SAMR1 mice (4.12% versus 4.19%). A total of 1 307 172 280 clean reads were obtained. Subsequently, we identified 63 DMRs from all cases in SAMP8 mice relative to SAMR1 mice. In addition, 26 DMR-related genes were detected. GO analyses revealed that these DMR-related genes were involved in regulating the development of AD from different aspects. Finally, three differentially expressed DMR-related genes ( Dlgap1 , [[TMEM51]] and Eif2ak2 ) that were most likely involved in AD were summarized and listed in detail. Our study provided a systematic exploration of DNA methylation profiles in SAMP8 mouse brain for the first time. These novel methylation sites may be considered strong future candidates to combat this life-threatening disease. The WGBS sequencing clean data and RNA-seq clean data have been deposited in the NCBI Sequence Read Archive (SRA).The accession number of WGBS is SRP097054. The accession number of RNA-seq is SRP096779. zws@bnu.edu.cn. Supplementary data are available at Bioinformatics online.<br /> |mesh-terms=* Aging<br /> * Alzheimer Disease<br /> * Animals<br /> * Brain<br /> * DNA Methylation<br /> * Disease Models, Animal<br /> * Male<br /> * Mice<br /> * Sequence Analysis, RNA<br /> * Whole Genome Sequencing<br /> <br /> |full-text-url=https://sci-hub.do/10.1093/bioinformatics/btx040<br /> }}</div>

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