https://transhumanist.ru/index.php?action=history&feed=atom&title=TMEM135 2026-04-23T05:57:27Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TMEM135&diff=4223&oldid=prev 2021-04-29T19:07:07Z

<p>Новая страница: «Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) ==Publications== {{medline-entry |title=Mouse [i]Tmem135[/i] mutation reveals a mechanism in...»</p> <p><b>Новая страница</b></p><div>Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Mouse [i]Tmem135[/i] mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27863209<br /> |abstract=While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the retina as well as pathologies observed in age-dependent retinal diseases, suggesting that the responsible gene regulates retinal aging, and its impairment results in age-dependent disease. We determined that a mutation in the transmembrane 135 ([i]Tmem135[/i]) is responsible for these phenotypes. We observed localization of [[TMEM135]] on mitochondria, and imbalance of mitochondrial fission and fusion in mutant [i]Tmem135[/i] as well as [i]Tmem135[/i] overexpressing cells, indicating that [[TMEM135]] is involved in the regulation of mitochondrial dynamics. Additionally, mutant retina showed higher sensitivity to oxidative stress. These results suggest that the regulation of mitochondrial dynamics through [[TMEM135]] is critical for protection from environmental stress and controlling the progression of retinal aging. Our study identified [[TMEM135]] as a critical link between aging and age-dependent diseases.<br /> |mesh-terms=* Adaptor Proteins, Signal Transducing<br /> * Aging<br /> * Animals<br /> * Mice<br /> * Mitochondria<br /> * Mitochondrial Dynamics<br /> * Mutant Proteins<br /> * Nuclear Proteins<br /> * Retinal Diseases<br /> |keywords=* ENU<br /> * age-dependent retinal diseases<br /> * aging<br /> * cell biology<br /> * mitochondrial dynamics<br /> * mouse<br /> * neuroscience<br /> * retina<br /> * retinal pigment epithelium<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117855<br /> }}</div>

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