https://transhumanist.ru/index.php?action=history&feed=atom&title=TFG 2026-04-10T20:33:35Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TFG&diff=4122&oldid=prev 2021-04-29T19:01:47Z

<p>Новая страница: «Protein TFG (TRK-fused gene protein) ==Publications== {{medline-entry |title=<a href="/TFG" title="TFG">TFG</a>-maintaining stability of overlooked <a href="/FANCD2" title="FANCD2">FANCD2</a> confers early DNA-damage res...»</p> <p><b>Новая страница</b></p><div>Protein TFG (TRK-fused gene protein)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[TFG]]-maintaining stability of overlooked [[FANCD2]] confers early DNA-damage response.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099537<br /> |abstract=Emerging Fanconi Anemia (FA) signaling in the field of cancer research annotates the extreme importance of its center player, Fanconi Anemia complementation group D2 ([[FANCD2]]) in protecting human cells from going awry. However, a previously-unrecognized form of [[FANCD2]], namely [[FANCD2]]-V2, is understudied. We report TRK-Fused Gene ([[TFG]]) is critical for roles played by [[FANCD2]]-V2 in early responses to DNA damage, but not for [[FANCD2]]-V1, the long-known form of [[FANCD2]]. [[FANCD2]]-V2 forms nuclear foci upon DNA damage, and both its focus appearance and disappearance are earlier than [[FANCD2]]-V1. The amino acid/aa 5-100 of [[TFG]] and the aa1437-1442 of [[FANCD2]]-V2 were identified to contribute to their interaction, which maintains the steady-state level of [[FANCD2]]-V2 protein. [[TFG]]Δaa5-100 or [[FANCD2]]-V2Δaa1437-1442-carrying cells could not show timely focus formation of [[FANCD2]]-V2 upon DNA damage and gained carcinogenicity over time. This study provides a previously-unknown key to unlock in-depth insights into maintaining genome stability, fostering translational studies on preventing, diagnosing and/or treating related diseases.<br /> <br /> |keywords=* DNA damage response<br /> * FANCD2<br /> * TFG<br /> * aging and cancer<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655164<br /> }}</div>

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