https://transhumanist.ru/index.php?action=history&feed=atom&title=TFEC 2026-04-20T20:36:15Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TFEC&diff=5336&oldid=prev 2021-05-12T13:39:40Z

<p>Новая страница: «Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) [BHLHE34] [TCFEC] [TFECL] ==Public...»</p> <p><b>Новая страница</b></p><div>Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) [BHLHE34] [TCFEC] [TFECL]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/8945990<br /> |abstract=A member of the fibroblast growth factor (FGF) family, keratinocyte growth factor (FGF-7 has unique specificity for epithelial cells. We investigated the role of FGF-7 in repair of proximal tubular damage caused by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine ([[TFEC]]). In situ hybridization localized FGF-7 to interstitial cells in the medulla and outer stripe of the outer medulla. Interstitial FGF-7 expression increased throughout the kidney 1 day after [[TFEC]] treatment. [[FGFR2]] IIIb mRNA was high in the papilla and medulla and also increased after [[TFEC]] administration. By in situ hybridization, [[FGFR2]] IIIb was localized to the tubular epithelium, particularly in collecting ducts. Proliferation of collecting duct epithelial cells increased in adult kidney after damage to the proximal tubule. [[FGFR2]] IIIb, but not FGF-7, mRNA was also expressed by rat proximal tubule epithelial (RPTE) cells in vitro, and FGF-7 increased DNA synthesis in RPTE. Thus [[FGFR2]] IIIb and FGF-7 expression is segregated between epithelial and interstitial cells forming a paracrine growth factor loop. These results raise the possibility that a novel paracrine growth loop is activated by chemical damage and regulates epithelial cell growth during tubular repair.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Cell Division<br /> * Cells, Cultured<br /> * Epithelial Cells<br /> * Epithelium<br /> * Fibroblast Growth Factor 10<br /> * Fibroblast Growth Factor 7<br /> * Fibroblast Growth Factors<br /> * Gene Expression Regulation<br /> * Growth Substances<br /> * Kidney<br /> * Kidney Tubules, Proximal<br /> * Male<br /> * RNA, Messenger<br /> * Rats<br /> * Rats, Inbred F344<br /> * Receptors, Fibroblast Growth Factor<br /> * Tissue Distribution<br /> * Wound Healing<br /> <br /> |full-text-url=https://sci-hub.do/10.1152/ajprenal.1996.271.5.F967<br /> }}</div>

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