https://transhumanist.ru/index.php?action=history&feed=atom&title=TEAD2 2026-06-13T14:48:30Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TEAD2&diff=5443&oldid=prev 2021-05-12T13:44:13Z

<p>Новая страница: «Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) [TEF4] ==Publications== {{medline-entry |title=Novel transcriptional targets of the...»</p> <p><b>Новая страница</b></p><div>Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) [TEF4]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Novel transcriptional targets of the [[SRY]]-HMG box transcription factor [[SOX4]] link its expression to the development of small cell lung cancer.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22084397<br /> |abstract=The HMG box transcription factor [[SOX4]] involved in neuronal development is amplified and overexpressed in a subset of lung cancers, suggesting that it may be a driver oncogene. In this study, we sought to develop this hypothesis including by defining targets of [[SOX4]] that may mediate its involvement in lung cancer. Ablating [[SOX4]] expression in [[SOX4]]-amplified lung cancer cells revealed a gene expression signature that included genes involved in neuronal development such as PCDHB, [[MYB]], [[RBP1]], and [[TEAD2]]. Direct recruitment of [[SOX4]] to gene promoters was associated with their upregulation upon ectopic overexpression of [[SOX4]]. We confirmed upregulation of the [[SOX4]] expression signature in a panel of primary lung tumors, validating their specific response by a comparison using embryonic fibroblasts from Sox4-deficient mice. Interestingly, we found that small cell lung cancer (SCLC), a subtype of lung cancer with neuroendocrine characteristics, was generally characterized by high levels of [[SOX2]], [[SOX4]], and [[SOX11]] along with the [[SOX4]]-specific gene expression signature identified. Taken together, our findings identify a functional role for SOX genes in SCLC, particularly for [[SOX4]] and several novel targets defined in this study.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blotting, Western<br /> * Carcinoma, Small Cell<br /> * Cell Line, Tumor<br /> * Chromatin Immunoprecipitation<br /> * Gene Expression<br /> * Humans<br /> * Lung Neoplasms<br /> * Mice<br /> * Promoter Regions, Genetic<br /> * Real-Time Polymerase Chain Reaction<br /> * SOXC Transcription Factors<br /> * Transcription, Genetic<br /> <br /> |full-text-url=https://sci-hub.do/10.1158/0008-5472.CAN-11-3506<br /> }}</div>

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