https://transhumanist.ru/index.php?action=history&feed=atom&title=TCF7L1 2026-04-08T01:41:16Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TCF7L1&diff=4245&oldid=prev 2021-04-29T19:08:10Z

<p>Новая страница: «Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3) [TCF3] ==Publications== {{medline-entry |title=<a href="/TCF7L1" title="TCF7L1">TCF7L1</a> promotes skin tumorigenesis ind...»</p> <p><b>Новая страница</b></p><div>Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3) [TCF3]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[TCF7L1]] promotes skin tumorigenesis independently of β-catenin through induction of [[LCN2]].<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28467300<br /> |abstract=The transcription factor [i][[TCF7L1]][/i] is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document [[TCF7L1]] upregulation in skin squamous cell carcinoma (SCC) and demonstrate that [[TCF7L1]] overexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemically induced mouse model of skin SCC. Additionally, we show that downregulation of [[TCF7L1]] and its paralogue [[TCF7L2]] reduces tumor growth in a xenograft model of human skin SCC. Using separation-of-function mutants, we show that [[TCF7L1]] promotes tumor growth, enhances cell migration, and overrides oncogenic RAS-induced senescence independently of its interaction with β-catenin. Through transcriptome profiling and combined gain- and loss-of-function studies, we identified [[LCN2]] as a major downstream effector of [[TCF7L1]] that drives tumor growth. Our findings establish a tumor-promoting role for [[TCF7L1]] in skin and elucidate the mechanisms underlying its tumorigenic capacity.<br /> |mesh-terms=* Animals<br /> * Carcinogenesis<br /> * Carcinoma, Squamous Cell<br /> * Disease Models, Animal<br /> * Gene Expression Profiling<br /> * Heterografts<br /> * Humans<br /> * Lipocalin-2<br /> * Mice<br /> * Skin Neoplasms<br /> * Transcription Factor 7-Like 1 Protein<br /> * beta Catenin<br /> |keywords=* TCF7L1<br /> * cancer biology<br /> * cell biology<br /> * cell migration<br /> * human<br /> * mouse<br /> * oncogene-induced senescence<br /> * skin squamous cell carcinoma<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438253<br /> }}</div>

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