https://transhumanist.ru/index.php?action=history&feed=atom&title=TAF7 2026-06-02T23:46:09Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=TAF7&diff=4218&oldid=prev 2021-04-29T19:06:53Z

<p>Новая страница: «Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II...»</p> <p><b>Новая страница</b></p><div>Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) [TAF2F] [TAFII55]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Basonuclin 1 deficiency causes testicular premature aging: [[BNC1]] cooperates with [[TAF7]]L to regulate spermatogenesis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31065688<br /> |abstract=Basonuclin ([[BNC1]]) is expressed primarily in proliferative keratinocytes and gametogenic cells. However, its roles in spermatogenesis and testicular aging were not clear. Previously we discovered a heterozygous [[BNC1]] truncation mutation in a premature ovarian insufficiency pedigree. In this study, we found that male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature aging. Genome-wide expression profiling and direct binding studies (by chromatin immunoprecipitation sequencing) with [[BNC1]] in mouse testis identified several spermatogenesis-specific gene promoters targeted by [[BNC1]] including kelch-like family member 10 (Klhl10), testis expressed 14 (Tex14), and spermatogenesis and centriole associated 1 (Spatc1). Moreover, biochemical analysis showed that [[BNC1]] was associated with TATA-box binding protein-associated factor 7 like ([[TAF7]]L), a germ cell-specific paralogue of the transcription factor IID subunit [[TAF7]], both in vitro and in testis, suggesting that [[BNC1]] might directly cooperate with [[TAF7]]L to regulate spermatogenesis. The truncation mutation disabled nuclear translocation of the [[BNC1]]/[[TAF7]]L complex, thus, disturbing expression of related genes and leading to testicular premature aging. Similarly, expressions of [[BNC1]], [[TAF7]]L, Y-box-binding protein 2 (YBX2), outer dense fiber of sperm tails 1 (ODF1), and glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (GAPDHS) were significantly decreased in the testis of men with non-obstructive azoospermia. The present study adds to the understanding of the physiology of male reproductive aging and the mechanism of spermatogenic failure in infertile men.<br /> <br /> |keywords=* BNC1<br /> * TAF7L<br /> * gene mutation<br /> * spermatogenesis<br /> * testicular aging<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052986<br /> }}</div>

OdysseusBot