https://transhumanist.ru/index.php?action=history&feed=atom&title=TAF1TAF1 - История изменений2026-08-21T18:00:43ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=TAF1&diff=5236&oldid=prevOdysseusBot: Новая страница: «Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription init...»2021-05-12T13:35:25Z<p>Новая страница: «Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription init...»</p>
<p><b>Новая страница</b></p><div>Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) [BA2R] [CCG1] [CCGS] [TAF2A]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22842574<br />
|abstract=TATA-box binding protein associated factor 1 ([[TAF1]]) protein is the largest and the essential component of the TFIID complex in the pathway of RNA polymerase II-mediated gene transcription, and it regulates transcription of a large number of genes related to cell division. The neuron-specific isoform of the [[TAF1]] gene (N-[[TAF1]]), which we reported previously, may have an essential role in neurons through transcriptional regulation of many neuron-specific genes. In the present study, we cloned the full-length cDNA that encodes the mouse homologue of N-[[TAF1]] (N-Taf1) protein. By carrying out of real time RT-PCR, we investigated the expression analysis of the N-Taf1 mRNA in mouse tissues and cell lines. As well as the human N-[[TAF1]], the N-Taf1 showed limited expression in the brain and neuroblastoma, whereas Taf1 expressed elsewhere. Furthermore, in mouse embryo head or mouse brain, mRNA expression of [[TAF1]] changes dramatically during development but N-Taf1 showed sustained expression. Our result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Base Sequence<br />
* Brain<br />
* Cell Division<br />
* Cell Line, Tumor<br />
* Cell Proliferation<br />
* Cloning, Molecular<br />
* Embryo, Mammalian<br />
* Exons<br />
* Gene Expression Regulation, Developmental<br />
* Head<br />
* Histone Acetyltransferases<br />
* Humans<br />
* Mice<br />
* Mice, Inbred BALB C<br />
* Molecular Sequence Data<br />
* Neurogenesis<br />
* Neurons<br />
* Open Reading Frames<br />
* Protein Isoforms<br />
* RNA, Messenger<br />
* TATA-Binding Protein Associated Factors<br />
* Transcription Factor TFIID<br />
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|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2012.07.081<br />
}}</div>OdysseusBot