https://transhumanist.ru/index.php?action=history&feed=atom&title=TAB2TAB2 - История изменений2026-08-30T08:23:14ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=TAB2&diff=5060&oldid=prevOdysseusBot: Новая страница: «TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2)...»2021-05-12T13:27:29Z<p>Новая страница: «TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2)...»</p>
<p><b>Новая страница</b></p><div>TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) [KIAA0733] [MAP3K7IP2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Expression analysis of the [[TAB2]] protein in adult mouse tissues.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17406806<br />
|abstract=The Interleukin-1 (IL-1) signaling component TAK1 binding protein 2 ([[TAB2]]) plays a role in activating the NFkappaB and JNK signaling pathways. Additionally, [[TAB2]] functions in the nucleus as a repressor of NFkappaB-mediated gene regulation. To obtain insight into the function of [[TAB2]] in the adult mouse, we analyzed the in vivo [[TAB2]] expression pattern. Cell lines and adult mouse tissues were analyzed for [[TAB2]] protein expression and localization. Immunohistochemical staining for [[TAB2]] protein revealed expression in the vascular endothelium of most tissues, hematopoietic cells and brain cells. While [[TAB2]] is localized in both the nucleus and the cytoplasm in cell lines, cytoplasmic localization predominates in hematopoietic tissues in vivo. The [[TAB2]] expression pattern shows striking similarities with previously reported IL-1 receptor expression and NFkappaB activation patterns, suggesting that [[TAB2]] in vivo is playing a role in these signaling pathways.<br />
|mesh-terms=* Adaptor Proteins, Signal Transducing<br />
* Aging<br />
* Animals<br />
* Bone Marrow<br />
* Cell Line<br />
* Cell Nucleus<br />
* Cells, Cultured<br />
* Cricetinae<br />
* Cytoplasm<br />
* Gene Expression Regulation<br />
* Isoenzymes<br />
* MAP Kinase Kinase Kinases<br />
* Mice<br />
* Organ Specificity<br />
* RNA, Messenger<br />
* Recombinant Proteins<br />
* Spleen<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770139<br />
}}</div>OdysseusBot