https://transhumanist.ru/index.php?action=history&feed=atom&title=SULT1B1 2026-06-23T11:21:39Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SULT1B1&diff=5469&oldid=prev 2021-05-12T13:45:21Z

<p>Новая страница: «Sulfotransferase family cytosolic 1B member 1 (EC 2.8.2.-) (ST1B1) (Sulfotransferase 1B1) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) [ST1B2...»</p> <p><b>Новая страница</b></p><div>Sulfotransferase family cytosolic 1B member 1 (EC 2.8.2.-) (ST1B1) (Sulfotransferase 1B1) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) [ST1B2] [SULT1B2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Postnatal ontogeny and hormonal regulation of sulfotransferase [[SULT1B1]] in male and female rats.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10381794<br /> |abstract=The ontogenic and hormonal regulation of a sulfotransferase, [[SULT1B1]], was examined. Hepatic RNA was isolated from rats of various ages from 1 to 90 days. The mRNA for [[SULT1B1]] is low for both sexes until a dramatic increase ( approximately 6-fold) occurs between 15 and 30 days of age in male rats. [[SULT1B1]] expression then decreases to half of the maximal level by 90 days of age. The increase in [[SULT1B1]] mRNA in female rats is less dramatic and occurs between 30 and 45 days of age. [[SULT1B1]] mRNA expression plateaus from 45 to 90 days in female rats. Expression of [[SULT1B1]] mRNA is comparable in adult male and female rats. RNA was isolated from hypophysectomized (HX) animals and HX animals treated with growth hormone [by either male (injection) or female (infusion) pattern], estradiol, progesterone, or testosterone. HX and HX plus growth hormone, or HX plus steroid replacement, did not alter [[SULT1B1]] mRNA expression. Pituitary-intact rats were treated with steroidal compounds dexamethasone (DEX) and pregnenolone-16alpha-carbonitrile (PCN). Both DEX and PCN increased expression of [[SULT1B1]] mRNA in male rats (4- and 3-fold, respectively). However, in female rats, only PCN induced [[SULT1B1]] mRNA (2-fold), whereas DEX did not induce [[SULT1B1]] in female rats. Analysis of [[SULT1B1]] protein expression indicated that only when [[SULT1B1]] mRNA was markedly increased, that is in DEX-treated male rats, was [[SULT1B1]] protein increased. Thus, although adult male and female rats have similar [[SULT1B1]] mRNA expressions, the patterns develop ontogenically differently. [[SULT1B1]] is not regulated by pituitary hormones and DEX induces [[SULT1B1]] protein in male rats.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Antibody Specificity<br /> * Blotting, Northern<br /> * Blotting, Western<br /> * Dexamethasone<br /> * Enzyme-Linked Immunosorbent Assay<br /> * Female<br /> * Glucocorticoids<br /> * Hormones<br /> * Hypophysectomy<br /> * Male<br /> * Organ Specificity<br /> * Pregnenolone Carbonitrile<br /> * RNA, Messenger<br /> * Rabbits<br /> * Rats<br /> * Rats, Sprague-Dawley<br /> * Sulfotransferases<br /> <br /> <br /> }}</div>

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