https://transhumanist.ru/index.php?action=history&feed=atom&title=SULT1A1 2026-04-13T15:41:41Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SULT1A1&diff=4054&oldid=prev 2021-04-29T18:58:16Z

<p>Новая страница: «Sulfotransferase 1A1 (EC 2.8.2.1) (ST1A1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST...»</p> <p><b>Новая страница</b></p><div>Sulfotransferase 1A1 (EC 2.8.2.1) (ST1A1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) [STP] [STP1] [OK/SW-cl.88]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28748955<br /> |abstract=The enormous variation in human lifespan is in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of death in the UK Biobank study (n=116,279) revealed 16 independent SNPs with significant Bayes factor at a 5% false discovery rate (FDR). Eleven of them replicate (5% FDR) in five independent longevity studies combined; all but three are depleted of the life-shortening alleles in older Biobank participants. Further analysis revealed that brain expression levels of nearby genes ([[RBM6]], [[SULT1A1]] and CHRNA5) might be causally implicated in longevity. Gene expression and caloric restriction experiments in model organisms confirm the conserved role for [[RBM6]] and [[SULT1A1]] in modulating lifespan.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Arylsulfotransferase<br /> * Bayes Theorem<br /> * Biomarkers<br /> * Disease<br /> * European Continental Ancestry Group<br /> * Female<br /> * Genome-Wide Association Study<br /> * Humans<br /> * Longevity<br /> * Male<br /> * Nerve Tissue Proteins<br /> * Polymorphism, Single Nucleotide<br /> * RNA-Binding Proteins<br /> * Receptors, Nicotinic<br /> * United Kingdom<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537485<br /> }}</div>

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