https://transhumanist.ru/index.php?action=history&feed=atom&title=STX3 2026-11-08T22:27:48Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=STX3&diff=5301&oldid=prev 2021-05-12T13:38:14Z

<p>Новая страница: «Syntaxin-3 [STX3A] ==Publications== {{medline-entry |title=Myelopoiesis in spleen-producing distinct dendritic-like cells. |pubmed-url=https://pubmed.ncbi.nlm.n...»</p> <p><b>Новая страница</b></p><div>Syntaxin-3 [STX3A]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Myelopoiesis in spleen-producing distinct dendritic-like cells.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22117595<br /> |abstract=Dendritic cells (DC) represent a heterogeneous class of antigen presenting cells (APC). Previously we reported a distinct myeloid dendritic-like cell present in spleen, as an in vivo counterpart to cells produced in murine spleen long-term cultures (LTC-DC). These cells, named &#039;L-DC&#039;, were found to be functionally and phenotypically distinct from conventional (c)DC, plasmacytoid (p)DC and monocytes. These results suggested that spleen may represent a niche for development of L-DC from endogenous progenitors. Adult murine spleen has now been investigated for the presence of L-DC progenitors. Lineage-negative (Lin)(-) ckit(lo) and Lin(-) ckit(hi) progenitor subsets were identified as candidate populations, and tested for ability to produce L-DC; in vitro upon co-culture with the spleen stromal line [[STX3]], and in vivo after adoptive therapy into mice. Both subsets colonized [[STX3]] stroma in vitro for L-DC production, indicating that they contained either a common or two distinct progenitors for L-DC. However, only the Lin(-) ckit(hi) subset gave progeny cells after adoptive transfer into lethally irradiated mice. In vivo development was however multilineage and not restricted to L-DC development. Multilineage reconstitution reflects long-term reconstituting haematopoietic stem cells (LT-HSC), suggesting a close relationship between L-DC progenitors and LT-HSC. L-DC were however produced in vivo in much higher number than monocytes/macrophages and cDC, indicating the presence of a specific L-DC progenitor within the Lin(-) ckit(hi) subset. A model is advanced for development of L-DC directly from haematopoietic progenitors in spleen and dependent on the spleen microenvironment.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Cell Differentiation<br /> * Cell Separation<br /> * Coculture Techniques<br /> * Dendritic Cells<br /> * Hematopoietic Stem Cells<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * Myelopoiesis<br /> * Spleen<br /> * Time Factors<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822703<br /> }}</div>

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