https://transhumanist.ru/index.php?action=history&feed=atom&title=SSTR5 2026-08-31T18:59:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SSTR5&diff=5684&oldid=prev 2021-05-12T13:55:18Z

<p>Новая страница: «Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) ==Publications== {{medline-entry |title=The effect of global <a href="/SSTR5" title="SSTR5">SSTR5</a> gene ablation on the endocrine pancr...»</p> <p><b>Новая страница</b></p><div>Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=The effect of global [[SSTR5]] gene ablation on the endocrine pancreas and glucose regulation in aging mice.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16026801<br /> |abstract=The purpose of this study was to examine the effect of global gene ablation of [[SSTR5]] on the endocrine pancreas, insulin secretion, and glucose tolerance in aging mice, as [[SSTR5]] is a primary regulator of insulin secretion in the mouse pancreas. Global [[SSTR5]]-/- mice were generated and genotypes were verified using Southern blot and RT-PCR. Glucose tolerance and in vivo insulin secretion in [[SSTR5]]-/- and WT mice were examined using intraperitoneal glucose tolerance test (IPGTT;1.2-2.0 mg/kg) at 3 and 12 months of age (n = 8 per group). Basal and glucose-stimulated insulin secretion in vitro was studied using the isolated perfused mouse pancreas model at 3 and 12 months. Pancreata were removed and levels of insulin, glucagon, somatostatin, and [[SSTR1]] were studied using immunohistochemical analysis along with H</div>

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