https://transhumanist.ru/index.php?action=history&feed=atom&title=SPTBN1SPTBN1 - История изменений2026-06-24T04:32:18ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=SPTBN1&diff=5711&oldid=prevOdysseusBot: Новая страница: «Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) [SPTB2] ==Publications== {{medline-entry |...»2021-05-12T13:56:24Z<p>Новая страница: «Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) [SPTB2] ==Publications== {{medline-entry |...»</p>
<p><b>Новая страница</b></p><div>Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) [SPTB2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22798246<br />
|abstract=To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, [[CTNNB1]], [[MEF2C]], [[SOX6]], and [[TNFRSF11B]] were associated with L1-4 or total hip BMDs. rs11898505 in [[SPTBN1]] gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.<br />
|mesh-terms=* Accidental Falls<br />
* Adult<br />
* Aged<br />
* Aging<br />
* Asian Continental Ancestry Group<br />
* Bone Density<br />
* China<br />
* Cohort Studies<br />
* Cross-Sectional Studies<br />
* Female<br />
* Genetic Association Studies<br />
* Hip Joint<br />
* Humans<br />
* Lumbar Vertebrae<br />
* MADS Domain Proteins<br />
* MEF2 Transcription Factors<br />
* Middle Aged<br />
* Myogenic Regulatory Factors<br />
* Osteoporosis, Postmenopausal<br />
* Osteoporotic Fractures<br />
* Osteoprotegerin<br />
* Polymorphism, Single Nucleotide<br />
* Radiography<br />
* Spectrin<br />
* Young Adult<br />
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|full-text-url=https://sci-hub.do/10.1007/s12020-012-9726-8<br />
}}</div>OdysseusBot