https://transhumanist.ru/index.php?action=history&feed=atom&title=SPG11 2026-05-14T16:13:49Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SPG11&diff=3950&oldid=prev 2021-04-29T18:53:15Z

<p>Новая страница: «Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) [KIAA1840] ==Publications== {{medline-entry |title=[i]Malassezia[/i] and Par...»</p> <p><b>Новая страница</b></p><div>Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) [KIAA1840]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[i]Malassezia[/i] and Parkinson&#039;s Disease.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396143<br /> |abstract=Parkinson&#039;s disease (PD) is a common debilitating neurodegenerative disease caused by a loss of dopamine neurons in the substantia nigra within the central nervous system (CNS). The process leading to this neuronal loss is poorly understood. Seborrheic dermatitis (SD) is a common benign inflammatory condition of the skin which mainly affects lipid-rich regions of the head and trunk. SD is caused by over proliferation of the lipophilic fungus [i]Malassezia[/i]. PD and SD are strongly associated. The increased PD risk following an SD diagnosis (OR = 1.69, 95% CI 1.36, 2.1; [i]p[/i] &lt; 0.001) reported by Tanner and colleagues remains unexplained. [i]Malassezia[/i] were historically considered commensals confined to the skin. However, many recent studies report finding [i]Malassezia[/i] in internal organs, including the CNS. This raises the possibility that [i]Malassezia[/i] might be directly contributing to PD. Several lines of evidence support this hypothesis. AIDS is causally associated with both parkinsonism and SD, suggesting that weak T cell-mediated control of commensal microbes such as [i]Malassezia[/i] might contribute to both. Genetic polymorphisms associated with PD ([i]LRRK2, [[GBA]], [[PINK1]], [[SPG11]], SNCA[/i]) increase availability of lipids within human cells, providing a suitable environment for [i]Malassezia[/i]. Four [i]LRRK2[/i] polymorphisms which increase PD risk also increase Crohn&#039;s disease risk; Crohn&#039;s disease is strongly associated with an immune response against fungi, particularly [i]Malassezia[/i]. Finally, [i]Malassezia[/i] hypha formation and melanin synthesis are stimulated by L-DOPA, which could promote [i]Malassezia[/i] invasiveness of dopamine neurons, and contribute to the accumulation of melanin in these neurons. Although [i]Malassezia[/i]&#039;s presence in the substantia nigra remains to be confirmed, if [i]Malassezia[/i] play a role in PD etiology, antifungal drugs should be tested as a possible therapeutic intervention.<br /> <br /> |keywords=* Malassezia<br /> * Parkinson&#039;s disease<br /> * immunodeficiency<br /> * immunosenescence<br /> * seborrheic dermatitis<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667642<br /> }}</div>

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