https://transhumanist.ru/index.php?action=history&feed=atom&title=SOSTDC1 2026-05-11T23:42:58Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SOSTDC1&diff=5178&oldid=prev 2021-05-12T13:32:50Z

<p>Новая страница: «Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) [USAG1] [CDA019]...»</p> <p><b>Новая страница</b></p><div>Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) [USAG1] [CDA019]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the &quot;Fountain of Youth&quot; to mediate healthful aging.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20227497<br /> |abstract=The nuclear vitamin D receptor ([[VDR]]) binds 1,25-dihydroxyvitamin D3 (1,25D), its high affinity renal endocrine ligand, to signal intestinal calcium and phosphate absorption plus bone remodeling, generating a mineralized skeleton free of rickets/osteomalacia with a reduced risk of osteoporotic fractures. 1,25D/[[VDR]] signaling regulates the expression of [[TRPV6]], BGP, [[SPP1]], [[LRP5]], RANKL and OPG, while achieving feedback control of mineral ions to prevent age-related ectopic calcification by governing [[CYP24A1]], [[PTH]], [[FGF23]], [[PHEX]], and klotho transcription. Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal [[CYP27B1]], and binds [[VDR]] to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits. [[VDR]] also affects Wnt signaling through direct interaction with beta-catenin, ligand-dependently blunting beta-catenin mediated transcription in colon cancer cells to attenuate growth, while potentiating beta-catenin signaling via [[VDR]] ligand-independent mechanisms in osteoblasts and keratinocytes to function osteogenically and as a pro-hair cycling receptor, respectively. Finally, [[VDR]] also drives the mammalian hair cycle in conjunction with the hairless corepressor by repressing [[SOSTDC1]], S100A8/S100A9, and [[PTH]]rP. Hair provides a shield against UV-induced skin damage and cancer in terrestrial mammals, illuminating another function of [[VDR]] that facilitates healthful aging.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Calcium<br /> * Cell Nucleus<br /> * Gene Expression Regulation<br /> * Humans<br /> * Keratinocytes<br /> * Mice<br /> * Models, Biological<br /> * Osteopontin<br /> * Phosphates<br /> * Receptors, Calcitriol<br /> * Signal Transduction<br /> * Wnt Proteins<br /> * beta Catenin<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906618<br /> }}</div>

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