https://transhumanist.ru/index.php?action=history&feed=atom&title=SLCO1B3SLCO1B3 - История изменений2026-04-09T07:14:17ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=SLCO1B3&diff=4667&oldid=prevOdysseusBot: Новая страница: «Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-trans...»2021-04-29T19:28:56Z<p>Новая страница: «Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-trans...»</p>
<p><b>Новая страница</b></p><div>Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) [LST2] [OATP1B3] [OATP8] [SLC21A8]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Paclitaxel-induced sensory peripheral neuropathy is associated with an [[ABCB1]] single nucleotide polymorphism and older age in Japanese.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28447211<br />
|abstract=Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, using genotype data from a prospective study of paclitaxel-related toxicity in Japanese patients with breast cancer. Peripheral blood mononuclear cells from 127 Japanese women with breast cancer who received weekly adjuvant paclitaxel were used to genotypes [[SLCO1B3]] T334G (rs4149117), [[CYP2C8]] A1196G (rs10509681), [[ABCB1]] C1236T (rs1128503), [[ABCB1]] G2677T/A (rs2032582), and [[ABCB1]] C3435T (rs1045642). Genotypic and clinical factors were investigated for associations with PIPN. Of the five SNPs evaluated, no SNPs were significantly associated with grade 2 or higher PIPN. However, [[ABCB1]] 1236 TT showed a trend to associate with grade 2 or higher PIPN compared to [[ABCB1]] CT/CC (odds ratio 2.1, 95% CI 0.991-4.548, p = 0.051). In subgroup analysis, patients ≥60 years old with an [[ABCB1]] 1236 TT had a higher incidence of ≥grade 2 PIPN compared to patients with CT or CC genotype (p = 0.027). On multivariable analysis, age ≥60 years and the [[ABCB1]] 1236 TT showed a significant association with ≥grade 2 PIPN (p = 0.005 and p = 0.034, respectively). [[ABCB1]] 1236 TT genotype and older age might be a predictor of PIPN, which diminishes quality of life of cancer survivors.<br />
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily B<br />
* Adult<br />
* Aged<br />
* Aging<br />
* Antineoplastic Agents, Phytogenic<br />
* Asian Continental Ancestry Group<br />
* Breast Neoplasms<br />
* Cytochrome P-450 CYP2C8<br />
* Female<br />
* Genotype<br />
* Humans<br />
* Incidence<br />
* Middle Aged<br />
* Organic Anion Transporters, Sodium-Independent<br />
* Paclitaxel<br />
* Peripheral Nervous System Diseases<br />
* Pharmacogenetics<br />
* Polymorphism, Single Nucleotide<br />
* Predictive Value of Tests<br />
* Prospective Studies<br />
* Sensory Receptor Cells<br />
* Solute Carrier Organic Anion Transporter Family Member 1B3<br />
|keywords=* ABCB1<br />
* CYP2C8<br />
* Older age<br />
* Paclitaxel-induced peripheral neuropathy<br />
* SLCO1B3<br />
|full-text-url=https://sci-hub.do/10.1007/s00280-017-3314-9<br />
}}</div>OdysseusBot