https://transhumanist.ru/index.php?action=history&feed=atom&title=SHOXSHOX - История изменений2026-11-09T08:54:57ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=SHOX&diff=5633&oldid=prevOdysseusBot: Новая страница: «Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) [PHOG] ==Publications== {{me...»2021-05-12T13:53:03Z<p>Новая страница: «Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) [PHOG] ==Publications== {{me...»</p>
<p><b>Новая страница</b></p><div>Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) [PHOG]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Statural growth in 31 Japanese patients with [[SHOX]] haploinsufficiency: support for a disadvantageous effect of gonadal estrogens.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15118270<br />
|abstract=Although gonadal estrogens are known to facilitate the development of skeletal lesion in [[SHOX]] haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly confirmed [[SHOX]] haploinsufficiency. The mean height SD score at the diagnosis of [[SHOX]] haploinsufficiency was similar between patients identified in childhood and those identified in adulthood (-2.7 /- 0.8 [n = 15] vs. -2.4 /- 0.7 [n = 16], P = 0.36), and was significantly lower in patients identified by the studies for short stature than in those ascertained by the familial studies of the probands both in childhood (-3.0 /- 0.6 [n = 11] vs. -1.8 /- 0.5 [n = 4], P = 0.0051) and in adulthood (-3.0 /- 0.9 [n = 5] vs. -2.2 /- 0.5 [n = 11], P = 0.040). Analysis of longitudinal paired growth data obtained in seven females showed a significantly different mean height SD score between childhood and adulthood (-2.3 /- 0.5 vs. -2.9 /- 0.8, P = 0.0060). The results imply that gonadal estrogens have a deleterious effect on pubertal growth in [[SHOX]] haploinsufficiency, and that the growth disadvantage is recognizable by longitudinal rather than cross-sectional growth studies.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aging<br />
* Asian Continental Ancestry Group<br />
* Body Height<br />
* Child<br />
* Estrogens<br />
* Female<br />
* Growth<br />
* Haplotypes<br />
* Homeodomain Proteins<br />
* Humans<br />
* Infant<br />
* Longitudinal Studies<br />
* Male<br />
* Ovary<br />
* Short Stature Homeobox Protein<br />
* Transcription Factors<br />
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|full-text-url=https://sci-hub.do/10.1507/endocrj.51.197<br />
}}</div>OdysseusBot