https://transhumanist.ru/index.php?action=history&feed=atom&title=SH3GL2 2026-04-06T11:33:10Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SH3GL2&diff=5133&oldid=prev 2021-05-12T13:30:38Z

<p>Новая страница: «Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) [CNSA2] [SH3D2A] ==Publications== {{medline-entry |tit...»</p> <p><b>Новая страница</b></p><div>Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) [CNSA2] [SH3D2A]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Polymorphisms associated with egg number at 300 days of age in chickens.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22002122<br /> |abstract=We looked for variations that could be associated with chicken egg number at 300 days of age (EN300) in seven genes of the hypothalamic-pituitary-gonadal axis, including gonadotrophin-releasing hormone-I (GnRH-I), GnRH receptor (GnRHR), neuropeptide Y (NPY), dopamine D2 receptor ([[DRD2]]), vasoactive intestinal polypeptide ([[VIP]]), [[VIP]] receptor-1 ([[VIP]]R-1), prolactin (PRL), and the QTL region between 87 and 105 cM of the Z chromosome. Ten mutations in the seven genes were chosen to do marker-trait association analyses in a population comprising 1310 chickens, which were obtained from a company located in Guangdong Province of China. The C1704887T of [[VIP]]R-1 was found to have a highly significant association with EN300. The T5841629C of [[DRD2]] and the C1715301T of [[VIP]]R-1 were significantly associated with EN300. A highly significant association was also found between the C1704887T-C1715301T haplotypes of [[VIP]]R-1 and EN300. H1H3 had the highest EN300. Four PCR-RFLP variations in the candidate QTL region were selected to investigate their genetic effects on EN300. The haplotypes of T32742468C-G32742603A in this region showed a highly significant association with EN300. Bioinformatics analyses showed that both T32742468C and G32742603A were located in intron 1 of the SH3-domain [[GRB2]]-like 2 ([[SH3GL2]]) gene. We conclude that five SNPs, including C1704887T and C1715301T of [[VIP]]R-1, T5841629C of [[DRD2]], and T32742468C and G32742603A of [[SH3GL2]], would be useful as markers for breeding to increase chicken EN300.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Chickens<br /> * Female<br /> * Hypothalamo-Hypophyseal System<br /> * Neuropeptide Y<br /> * Ovum<br /> * Polymorphism, Genetic<br /> * Prolactin<br /> * Receptors, Dopamine D2<br /> * Receptors, LHRH<br /> * Receptors, Vasoactive Intestinal Polypeptide, Type I<br /> * Sex Chromosomes<br /> * Vasoactive Intestinal Peptide<br /> <br /> |full-text-url=https://sci-hub.do/10.4238/2011.October.3.5<br /> }}</div>

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