https://transhumanist.ru/index.php?action=history&feed=atom&title=SFTPD 2026-11-08T23:37:45Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SFTPD&diff=5478&oldid=prev 2021-05-12T13:45:52Z

<p>Новая страница: «Pulmonary surfactant-associated protein D precursor (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) [COLEC7] [PSPD] [SFTP4] ==Publications== {{medline-...»</p> <p><b>Новая страница</b></p><div>Pulmonary surfactant-associated protein D precursor (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) [COLEC7] [PSPD] [SFTP4]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20448057<br /> |abstract=Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and abnormal inflammatory responses to noxious stimuli. Surfactant protein-D ([[SFTPD]]) is immunomodulatory and essential to host defense. We hypothesized that polymorphisms in [[SFTPD]] could influence the susceptibility to COPD. We genotyped six single-nucleotide polymorphisms (SNPs) in surfactant protein D in 389 patients with COPD in the National Emphysema Treatment Trial (NETT) and 472 smoking control subjects from the Normative Aging Study (NAS). Case-control association analysis was performed using Cochran-Armitage trend tests and multivariate logistic regression. The replication of significant associations was attempted in the Boston Early-Onset COPD Study, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study, and the Bergen Cohort. We also correlated [[SFTPD]] genotypes with serum concentrations of surfactant protein-D (SP-D) in the ECLIPSE Study. In the NETT-NAS case-control analysis, four [[SFTPD]] SNPs were associated with susceptibility to COPD: rs2245121 (P = 0.01), rs911887 (P = 0.006), rs6413520 (P = 0.004), and rs721917 (P = 0.006). In the family-based analysis of the Boston Early-Onset COPD Study, rs911887 was associated with prebronchodilator and postbronchodilator FEV(1) (P = 0.003 and P = 0.02, respectively). An intronic SNP in [[SFTPD]], rs7078012, was associated with COPD in the ECLIPSE Study and the Bergen Cohort. Multiple [[SFTPD]] SNPs were associated with serum SP-D concentrations in the ECLIPSE Study. We demonstrated an association of polymorphisms in [[SFTPD]] with COPD in multiple populations. We demonstrated a correlation between [[SFTPD]] SNPs and SP-D protein concentrations. The SNPs associated with COPD and SP-D concentrations differed, suggesting distinct genetic influences on susceptibility to COPD and SP-D concentrations.<br /> |mesh-terms=* Aged<br /> * Aging<br /> * Case-Control Studies<br /> * Cohort Studies<br /> * Female<br /> * Genetic Predisposition to Disease<br /> * Genotype<br /> * Humans<br /> * Inflammation<br /> * Longitudinal Studies<br /> * Male<br /> * Middle Aged<br /> * Polymorphism, Genetic<br /> * Polymorphism, Single Nucleotide<br /> * Prospective Studies<br /> * Pulmonary Disease, Chronic Obstructive<br /> * Pulmonary Surfactant-Associated Protein D<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095932<br /> }}</div>

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