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2021-05-12T13:50:41Z

Новая страница: «Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) [...»

Новая страница

Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) [KIAA1928] [LZTR2] [RGPR] [SEC16S]

==Publications==

{{medline-entry
|title=Candidate gene association study of BMI-related loci, weight, and adiposity in old age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23160366
|abstract=Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near [[GNPDA2]] was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither [[GNPDA2]] nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near [[SEC16B]] was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.
|mesh-terms=* Adiposity
* African Americans
* Aged
* Aged, 80 and over
* Aging
* Body Mass Index
* Body Weight
* European Continental Ancestry Group
* Female
* Gene Expression Regulation
* Genetic Loci
* Genetic Predisposition to Disease
* Genetic Testing
* Genome, Human
* Humans
* Male
* Obesity
* Overweight
* Phenotype
* Polymorphism, Single Nucleotide
* Prospective Studies
* Sampling Studies
* United States
|keywords=* Aging
* Genetics
* Obesity
* SNPs.
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660116
}}
{{medline-entry
|title=Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21102462
|abstract=To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at [[LIN28B]] (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near [[FTO]], [[SEC16B]], [[TRA2B]] and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, [[CRTC1]] and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, [[PCSK2]] and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
|mesh-terms=* Adolescent
* Aging
* Body Height
* Body Size
* Child
* DNA Copy Number Variations
* Female
* Genetic Loci
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Inheritance Patterns
* Menarche
* Obesity
* Polymorphism, Single Nucleotide
* Quantitative Trait Loci
* Reproducibility of Results
* Time Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140055
}}

SEC16B - История изменений

OdysseusBot: Новая страница: «Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) [...»