https://transhumanist.ru/index.php?action=history&feed=atom&title=SCRIB 2026-06-11T07:21:49Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SCRIB&diff=4291&oldid=prev 2021-04-29T19:10:36Z

<p>Новая страница: «Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) [CRIB1] [KIAA0147] [LAP4] [SCRB1] [VARTUL] ==Publications== {{medline-entry |title=Scribble is requi...»</p> <p><b>Новая страница</b></p><div>Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) [CRIB1] [KIAA0147] [LAP4] [SCRB1] [VARTUL]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27179074<br /> |abstract=The cell polarity protein scribble ([[SCRIB]]) is a crucial regulator of polarization, cell migration and tumorigenesis. Whereas [[SCRIB]] is known to regulate early stages of mouse mammary gland development, its function in the adult gland is not known. Using an inducible RNA interference (RNAi) mouse model for downregulating [[SCRIB]] expression, we report an unexpected role for [[SCRIB]] as a positive regulator of cell proliferation during pregnancy-associated mammary alveologenesis. [[SCRIB]] was required in the epithelial cell compartment of the mammary gland. Lack of [[SCRIB]] attenuated prolactin-induced activation of the [[JAK2]]-STAT5 signaling pathway. In addition, loss of [[SCRIB]] resulted in the downregulation of prolactin receptor (PRLR) at cell surface and its accumulation in intracellular structures that express markers of the Golgi complex and the recycling endosome. Unlike its role in virgin gland as a negative regulator cell proliferation, [[SCRIB]] is a positive regulator of mammary epithelial cell proliferation during pregnancy.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Epithelial Cells<br /> * Female<br /> * Gene Knockdown Techniques<br /> * Intracellular Signaling Peptides and Proteins<br /> * Janus Kinase 2<br /> * Mammary Glands, Animal<br /> * Mice<br /> * Organogenesis<br /> * Pregnancy<br /> * Prolactin<br /> * Receptors, Prolactin<br /> * STAT5 Transcription Factor<br /> * Signal Transduction<br /> |keywords=* Mammary alveologenesis<br /> * Proliferation<br /> * Scribble<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920253<br /> }}</div>

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