https://transhumanist.ru/index.php?action=history&feed=atom&title=SCAMP4 2026-08-22T08:33:59Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=SCAMP4&diff=4423&oldid=prev 2021-04-29T19:17:28Z

<p>Новая страница: «Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4) ==Publications== {{medline-entry |title=<a href="/SCAMP4" title="SCAMP4">SCAMP4</a> enhances the senescent...»</p> <p><b>Новая страница</b></p><div>Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[SCAMP4]] enhances the senescent cell secretome.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29967290<br /> |abstract=The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 ([[SCAMP4]]) levels were strikingly elevated on the surface of senescent cells compared with proliferating cells. Interestingly, silencing [[SCAMP4]] in senescent fibroblasts reduced the secretion of SASP factors, including interleukin 6 (IL6), IL8, growth differentiation factor 15 (GDF-15), C-X-C motif chemokine ligand 1 (CXCL1), and [[IL7]], while, conversely, [[SCAMP4]] overexpression in proliferating fibroblasts increased SASP factor secretion. Our results indicate that [[SCAMP4]] accumulates on the surface of senescent cells, promotes SASP factor secretion, and critically enhances the SASP phenotype.<br /> |mesh-terms=* Carrier Proteins<br /> * Cell Line<br /> * Cell Proliferation<br /> * Cellular Senescence<br /> * Fibroblasts<br /> * Gene Silencing<br /> * Humans<br /> * Membrane Proteins<br /> * Proteasome Endopeptidase Complex<br /> * Ubiquitin<br /> |keywords=* SCAMP4<br /> * cellular senescence<br /> * human diploid fibroblasts<br /> * senescence-associated secretory phenotype (SASP)<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075036<br /> }}</div>

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