https://transhumanist.ru/index.php?action=history&feed=atom&title=S100P 2026-10-21T23:01:19Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=S100P&diff=4403&oldid=prev 2021-04-29T19:16:19Z

<p>Новая страница: «Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) [S100E] ==Publications== {{medline-entry |title=Canc...»</p> <p><b>Новая страница</b></p><div>Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) [S100E]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Cancer-associated [[S100P]] protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26967060<br /> |abstract=[[S100P]] belongs to the S100 family of calcium-binding proteins regulating diverse cellular processes. Certain S100 family members (S100A4 and S100B) are associated with cancer and used as biomarkers of metastatic phenotype. Also [[S100P]] is abnormally expressed in tumors and implicated in migration-invasion, survival, and response to therapy. Here we show that [[S100P]] binds the tumor suppressor protein p53 as well as its negative regulator HDM2, and that this interaction perturbs the p53-HDM2 binding and increases the p53 level. Paradoxically, the [[S100P]]-induced p53 is unable to activate its transcriptional targets hdm2, p21WAF, and bax following the DNA damage. This appears to be related to reduced phosphorylation of serine residues in both N-terminal and C-terminal regions of the p53 molecule. Furthermore, the [[S100P]] expression results in lower levels of pro-apoptotic proteins, in reduced cell death response to cytotoxic treatments, followed by stimulation of therapy-induced senescence and increased clonogenic survival. Conversely, the [[S100P]] silencing suppresses the ability of cancer cells to survive the DNA damage and form colonies. Thus, we propose that the oncogenic role of [[S100P]] involves binding and inactivation of p53, which leads to aberrant DNA damage responses linked with senescence and escape to proliferation. Thereby, the [[S100P]] protein may contribute to the outgrowth of aggressive tumor cells resistant to cytotoxic therapy and promote cancer progression. <br /> |mesh-terms=* Calcium-Binding Proteins<br /> * Cell Line, Tumor<br /> * Cellular Senescence<br /> * Drug Resistance, Neoplasm<br /> * Humans<br /> * Neoplasm Proteins<br /> * Proto-Oncogene Proteins c-mdm2<br /> * Tumor Suppressor Protein p53<br /> |keywords=* HDM2<br /> * S100P calcium-binding protein<br /> * cell death<br /> * p53 tumor suppressor<br /> * therapy-induced senescence<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008377<br /> }}</div>

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