https://transhumanist.ru/index.php?action=history&feed=atom&title=S100A11S100A11 - История изменений2026-05-18T11:03:50ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=S100A11&diff=5088&oldid=prevOdysseusBot: Новая страница: «Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Contains: Protein S100-A11, N...»2021-05-12T13:28:39Z<p>Новая страница: «Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Contains: Protein S100-A11, N...»</p>
<p><b>Новая страница</b></p><div>Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Contains: Protein S100-A11, N-terminally processed] [MLN70] [S100C]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=S100-mediated signal transduction in the nervous system and neurological diseases.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16171556<br />
|abstract=This article presents new information regarding the complement/level of S100 family members expressed in the brain and reviews the contribution of brain S100 family members to nervous system function and disease. A total of ten S100 family members are reported in the literature to be expressed in brain -[[S100A1]], [[S100A2]], [[S100A4]], [[S100A5]], [[S100A6]], [[[[S100A1]]0]], [[S100A1]]1, [[[[S100A1]]3]], [[S100B]], and [[S100Z]]. Quantitative Northern blot analysis detected no [[S100A3]], [[S100A8]], [[S100A9]] or [[S100A1]]4 mRNA in mouse brain suggesting that these family members are not expressed in the brain. In addition, there was a 100-fold range in the mRNA levels for the six family members that were detected in mouse brain: [[S100A1]]/[[S100B]] levels were 5-fold higher than [[S100A6]]/[[[[S100A1]]0]] levels and 100-fold higher than [[S100A4]]/[[[[S100A1]]3]] levels. Five of these six family members (S1100A1, [[S100A6]], [[[[S100A1]]0]], [[[[S100A1]]3]], and [[S100B]]) exhibited age-dependent increases in expression in adult mice that ranged from 5- to 20-fold. Although previous studies on S100 function in the nervous system have focused on [[S100B]], other family members ([[S100A1]], [[S100A3]], [[S100A4]], [[S100A5]]) have been implicated in neurological diseases. Like [[S100B]], intra- and inter-cellular forms of these family members have been linked to cell growth, cell differentiation, and apoptotic pathways. Studies presented here demonstrate that ablation of [[S100A1]] expression in PC12 cells results in increased resistance to Abeta peptide induced cell death, stabilization of intracellular [Ca2 ] homeostasis, and reduced amyloid precursor protein expression. Altogether, these results confirm that S100-mediated signal transduction pathways play an important role in nervous system function/disease and implicate [[S100A1]] in the neuronal cell dysfunction/death that occurs in Alzheimer's disease.<br />
|mesh-terms=* Aging<br />
* Alzheimer Disease<br />
* Amyloid beta-Peptides<br />
* Amyloid beta-Protein Precursor<br />
* Animals<br />
* Apoptosis<br />
* Brain Chemistry<br />
* Calcium<br />
* Cell Differentiation<br />
* Cell Line<br />
* Cell Proliferation<br />
* Gene Expression Regulation<br />
* Homeostasis<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Nervous System Diseases<br />
* Nervous System Physiological Phenomena<br />
* Neurons<br />
* Peptide Fragments<br />
* S100 Proteins<br />
* Signal Transduction<br />
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