https://transhumanist.ru/index.php?action=history&feed=atom&title=RNF11 2026-06-03T06:38:09Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=RNF11&diff=5118&oldid=prev 2021-05-12T13:30:00Z

<p>Новая страница: «RING finger protein 11 [CGI-123] ==Publications== {{medline-entry |title=<a href="/index.php?title=WWP1&amp;action=edit&amp;redlink=1" class="new" title="WWP1 (страница не существует)">WWP1</a>: a versatile ubiquitin E3 ligase in signaling and diseases. |pubmed-url=https:...»</p> <p><b>Новая страница</b></p><div>RING finger protein 11 [CGI-123]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[WWP1]]: a versatile ubiquitin E3 ligase in signaling and diseases.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22051607<br /> |abstract=WW domain-containing E3 ubiquitin protein ligase 1 ([[WWP1]]) is a multifunction protein containing an N-terminal [[C2]] domain, four tandem WW domains for substrate binding, and a C-terminal catalytic HECT domain for ubiquitin transferring. [[WWP1]] has been suggested to function as the E3 ligase for several PY motif-containing proteins, such as Smad2, [[KLF5]], p63, ErbB4/HER4, [[RUNX2]], JunB, [[RNF11]], SPG20, and Gag, as well as several non-PY motif containing proteins, such as TβR1, Smad4, [[KLF2]], and [[EPS15]]. [[WWP1]] regulates a variety of cellular biological processes including protein trafficking and degradation, signaling, transcription, and viral budding. [[WWP1]] has been implicated in several diseases, such as cancers, infectious diseases, neurological diseases, and aging. In this review article, we extensively summarize the current knowledge of [[WWP1]] with special emphasis on the roles and action of mechanism of [[WWP1]] in signaling and human diseases.<br /> |mesh-terms=* Aging<br /> * ErbB Receptors<br /> * Gene Expression<br /> * Humans<br /> * Infections<br /> * Kruppel-Like Transcription Factors<br /> * Neoplasms<br /> * Nervous System Diseases<br /> * Protein Structure, Tertiary<br /> * Signal Transduction<br /> * Transforming Growth Factor beta<br /> * Tumor Suppressor Protein p53<br /> * Ubiquitin-Protein Ligases<br /> * Ubiquitination<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/s00018-011-0871-7<br /> }}</div>

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