https://transhumanist.ru/index.php?action=history&feed=atom&title=RGS1RGS1 - История изменений2026-04-09T00:04:55ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=RGS1&diff=5662&oldid=prevOdysseusBot: Новая страница: «Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20) [1R20] [BL34] [IER1] ==Publications== {{medline-entry |...»2021-05-12T13:54:16Z<p>Новая страница: «Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20) [1R20] [BL34] [IER1] ==Publications== {{medline-entry |...»</p>
<p><b>Новая страница</b></p><div>Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20) [1R20] [BL34] [IER1]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Increased baclofen-stimulated G protein coupling and deactivation in rat brain cortex during development.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15246693<br />
|abstract=The number and affinity of GABA(B) receptors (assayed by the specific antagonist [(3)H]CGP54626A) was unchanged when compared in carefully washed cerebrocortical membranes from young (12-day-old) and adult (90-day-old) rats. In contrast, high-affinity GTPase activity, both basal and baclofen-stimulated was significantly higher (by 45% and 56%, respectively) in adult than in young rats. Similar results were obtained by concomitant determination of agonist (baclofen)-stimulated GTP gamma S binding. Under standard conditions, baclofen-stimulated GTPase activity was further considerably enhanced by exogenously added regulator of G protein function, [[RGS1]], but not by [[RGS1]]6. [[RGS1]]6 was able to affect agonist-stimulated GTPase activity only in the presence of markedly increase substrate (GTP) concentrations. [[RGS1]] alone slightly increased GTPase activity in adult rats, but neither [[RGS1]] nor [[RGS1]]6 influenced GTPase activity in membrane preparations isolated from young animals. These findings indicate increasing functional activity of trimeric G protein(s) involved in GABAergic transmission in the developing rat brain cortex and suggest a high potential of [[RGS1]] in regulation of high-affinity GTPase activity.<br />
|mesh-terms=* Aging<br />
* Analysis of Variance<br />
* Animals<br />
* Animals, Newborn<br />
* Baclofen<br />
* Cerebral Cortex<br />
* Dose-Response Relationship, Drug<br />
* Drug Interactions<br />
* GABA Agonists<br />
* GTP Phosphohydrolases<br />
* GTP-Binding Proteins<br />
* Guanosine 5'-O-(3-Thiotriphosphate)<br />
* Male<br />
* Organophosphorus Compounds<br />
* Protein Binding<br />
* Proteins<br />
* RGS Proteins<br />
* Radioligand Assay<br />
* Rats<br />
* Tritium<br />
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|full-text-url=https://sci-hub.do/10.1016/j.devbrainres.2004.03.014<br />
}}</div>OdysseusBot