https://transhumanist.ru/index.php?action=history&feed=atom&title=RELN 2026-10-27T16:47:53Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=RELN&diff=5201&oldid=prev 2021-05-12T13:33:56Z

<p>Новая страница: «Reelin precursor (EC 3.4.21.-) ==Publications== {{medline-entry |title=Neocortical <a href="/RELN" title="RELN">RELN</a> promoter methylation increases significantly after puberty. |pubmed-...»</p> <p><b>Новая страница</b></p><div>Reelin precursor (EC 3.4.21.-)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Neocortical [[RELN]] promoter methylation increases significantly after puberty.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19952965<br /> |abstract=Reelin plays a pivotal role in neurodevelopment. Excessive [[RELN]] promoter methylation and/or decreased [[RELN]] gene expression have been described in schizophrenia and autism. We assessed [[RELN]] promoter methylation in post-mortem temporocortical tissue (Brodmann Area 41/42) of three prepuberal and six postpuberal normal individuals. The former display very little or no methylation, whereas most postpuberal individuals are heavily methylated, especially at CpG positions located between -131 and -98 bp (prepuberal vs. postpuberal, P&lt;0.05). Sex hormones thus seemingly boost DNA methylation at the [[RELN]] promoter. This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors, both typically occurring at puberty.<br /> |mesh-terms=* Adolescent<br /> * Adult<br /> * Age of Onset<br /> * Aging<br /> * Autistic Disorder<br /> * Cell Adhesion Molecules, Neuronal<br /> * Child<br /> * Child, Preschool<br /> * CpG Islands<br /> * DNA Methylation<br /> * Epigenesis, Genetic<br /> * Extracellular Matrix Proteins<br /> * Female<br /> * Gene Expression Regulation, Developmental<br /> * Genetic Markers<br /> * Gonadal Steroid Hormones<br /> * Humans<br /> * Male<br /> * Neocortex<br /> * Nerve Tissue Proteins<br /> * Promoter Regions, Genetic<br /> * Puberty<br /> * Schizophrenia<br /> * Serine Endopeptidases<br /> * Temporal Lobe<br /> * Up-Regulation<br /> * Young Adult<br /> <br /> |full-text-url=https://sci-hub.do/10.1097/WNR.0b013e328334b343<br /> }}</div>

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