https://transhumanist.ru/index.php?action=history&feed=atom&title=RDH12 2026-06-14T00:30:43Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=RDH12&diff=5626&oldid=prev 2021-05-12T13:52:46Z

<p>Новая страница: «Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) [SDR7C2] ==Publicati...»</p> <p><b>Новая страница</b></p><div>Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) [SDR7C2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Retinol dehydrogenases [[RDH11]] and [[RDH12]] in the mouse retina: expression levels during development and regulation by oxidative stress.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18326732<br /> |abstract=[[RDH11]] and [[RDH12]] are closely related retinol dehydrogenases expressed in the retina. [[RDH12]] has been linked to the early-onset retinal dystrophy Leber congenital amaurosis, whereas [[RDH11]] has not been associated with human disease. To understand their physiological roles, the authors investigated their expression during development and their regulation by light-induced oxidative stress in mouse retina. Quantitative RT-PCR and immunoblot analysis were used for quantification of [[RDH11]] and [[RDH12]] during development and oxidative stress. Expression during development was measured between embryonic day (E) 12 and postnatal day (P) 210 (7 months) in C57BL/6 mouse eyes. Expression during light-induced oxidative stress was measured between 2 and 24 hours of exposure to light in BALB/c mouse retina. The [[RDH11]] level was low and remarkably constant during development and oxidative stress. [[RDH12]] expression started at P7 and increased until P30 to approximately sevenfold higher than [[RDH11]]. Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of [[RDH12]] protein. The low and constant expression of [[RDH11]] suggested a housekeeping function for this enzyme. The onset of [[RDH12]] expression during the maturation of photoreceptor cells suggested a function related to the visual process. The light-induced rapid decrease of [[RDH12]] protein, preceding the decrease of the mRNA, suggested a specific degradation of the protein rather than a regulation of gene expression.<br /> |mesh-terms=* Aging<br /> * Alcohol Oxidoreductases<br /> * Animals<br /> * Gene Expression Regulation, Developmental<br /> * Immunoblotting<br /> * In Situ Hybridization<br /> * Light<br /> * Mice<br /> * Mice, Inbred BALB C<br /> * Mice, Inbred C57BL<br /> * Mice, Knockout<br /> * Oxidative Stress<br /> * Oxidoreductases<br /> * RNA, Messenger<br /> * Radiation Injuries, Experimental<br /> * Retina<br /> * Retinal Degeneration<br /> * Retinal Dehydrogenase<br /> * Reverse Transcriptase Polymerase Chain Reaction<br /> * Transcription, Genetic<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366097<br /> }}</div>

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