https://transhumanist.ru/index.php?action=history&feed=atom&title=RAB27ARAB27A - История изменений2026-06-22T02:00:31ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=RAB27A&diff=4088&oldid=prevOdysseusBot: Новая страница: «Ras-related protein Rab-27A (EC 3.6.5.2) (Rab-27) (GTP-binding protein Ram) [RAB27] ==Publications== {{medline-entry |title=Reduced expression level of the cycl...»2021-04-29T18:59:54Z<p>Новая страница: «Ras-related protein Rab-27A (EC 3.6.5.2) (Rab-27) (GTP-binding protein Ram) [RAB27] ==Publications== {{medline-entry |title=Reduced expression level of the cycl...»</p>
<p><b>Новая страница</b></p><div>Ras-related protein Rab-27A (EC 3.6.5.2) (Rab-27) (GTP-binding protein Ram) [RAB27]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Reduced expression level of the cyclic adenosine monophosphate response element-binding protein contributes to lung aging.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23991634<br />
|abstract=Lung aging is associated with morphological and physiological changes in which alterations in transcription factors, including the cyclic adenosine monophosphate response element-binding protein (CREB), could play a role. We studied CREB in lung tissue from mice at different ages and in response to known age-related factors (e.g., cellular senescence and matrix modifications with advanced glycation end-products [AGEs]). Our study shows that protein but not mRNA levels of CREB are reduced in the lungs of old mice. CREB reduction was also observed in senescent human lung fibroblasts (WI-38, LuFi) and human lung epithelial cells (A549) cultured on AGE-modified collagen matrix. Reduction of CREB protein is partially based on pre- and posttranslational modifications as exhibited by an increase in the CREB-regulating microRNA 34b and CREB ubiquitination. Permanent down-regulation of CREB in lung cells impaired cell proliferation and viability and increased the number of cells with senescence-associated β-galactosidase activity. CREB down-regulation was accompanied by the reduced expression of 165 genes in WI-38 fibroblasts and A549 epithelial cells, of which 15 genes showed a reduced expression in lung tissues of old mice. The CREB-dependent reduction in [[RAB27A]] coding for the Ras-related protein Rab27A and [[IGFBP3]] coding for the insulin-like growth factor-binding protein 3 has been confirmed for aged lung tissue, senescent fibroblasts, and lung epithelial cells on AGE-modified collagen. Our data demonstrate that the reduced protein expression of CREB might play a significant role in lung aging by modifying the transcription of [[RAB27A]], [[IGFBP3]], and other target genes. <br />
|mesh-terms=* Aging<br />
* Animals<br />
* Cell Line, Tumor<br />
* Cell Proliferation<br />
* Cell Survival<br />
* Cellular Senescence<br />
* Cyclic AMP<br />
* Cyclic AMP Response Element-Binding Protein<br />
* Down-Regulation<br />
* Epithelial Cells<br />
* Fibroblasts<br />
* Humans<br />
* Insulin-Like Growth Factor Binding Protein 3<br />
* Lung<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* MicroRNAs<br />
* Protein Modification, Translational<br />
* RNA Processing, Post-Transcriptional<br />
* Ubiquitination<br />
* beta-Galactosidase<br />
* rab GTP-Binding Proteins<br />
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|full-text-url=https://sci-hub.do/10.1165/rcmb.2013-0057OC<br />
}}</div>OdysseusBot