https://transhumanist.ru/index.php?action=history&feed=atom&title=PXN 2026-04-16T19:29:20Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PXN&diff=4136&oldid=prev 2021-04-29T19:02:34Z

<p>Новая страница: «Paxillin ==Publications== {{medline-entry |title=pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans. |pubmed-url=https:...»</p> <p><b>Новая страница</b></p><div>Paxillin<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26194821<br /> |abstract=C. elegans has two functional peroxidasins ([[PXN]]), [[PXN]]-1 and [[PXN]]-2. [[PXN]]-2 is essential to consolidate the extracellular matrix during development and is suggested to interact with [[PXN]]-1 antagonistically. pxn-1 is involved in neuronal development and possibly maintenance; therefore, we investigated the relationship between pxn-1 and pxn-2 in neuronal development and in aging. During neuronal development, defects caused by pxn-1 overexpression were suppressed by overexpression of both pxn-1 and pxn-2. In neuronal aging process, pxn-1 mutants showed less age-related neuronal defects, such as neuronal outgrowth, neuronal wavy processes, and enhanced short-term memory performance. In addition, pxn-2 overexpressing animals retained an intact neuronal morphology when compared with age-matched controls. Consistent with these results, overexpression of both pxn-1 and pxn-2 restored the severe neuronal defects present with pxn-1 overexpression. These results implied that there is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2. <br /> |mesh-terms=* Aging<br /> * Animals<br /> * Caenorhabditis elegans<br /> * Caenorhabditis elegans Proteins<br /> * Models, Animal<br /> * Neurogenesis<br /> * Peroxiredoxins<br /> |keywords=* C. elegans<br /> * antagonistic relationship<br /> * neuronal aging<br /> * neuronal development<br /> * pxn-1<br /> * pxn-2<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546945<br /> }}</div>

OdysseusBot