https://transhumanist.ru/index.php?action=history&feed=atom&title=PTPN3 2026-06-17T19:41:36Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PTPN3&diff=5318&oldid=prev 2021-05-12T13:38:56Z

<p>Новая страница: «Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) [PTPH1] ==Publications== {{medline-entry |title=Normal...»</p> <p><b>Новая страница</b></p><div>Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) [PTPH1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Normal TCR signal transduction in mice that lack catalytically active [[PTPN3]] protein tyrosine phosphatase.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17339465<br /> |abstract=[[PTPN3]] (PTPH1) is a cytoskeletal protein tyrosine phosphatase that has been implicated as a negative regulator of early TCR signal transduction and T cell activation. To determine whether [[PTPN3]] functions as a physiological negative regulator of TCR signaling in primary T cells, we generated gene-trapped and gene-targeted mouse strains that lack expression of catalytically active [[PTPN3]]. [[PTPN3]] phosphatase-negative mice were born in expected Mendelian ratios and exhibited normal growth and development. Furthermore, numbers and ratios of T cells in primary and secondary lymphoid organs were unaffected by the [[PTPN3]] mutations and there were no signs of spontaneous T cell activation in the mutant mice with increasing age. TCR-induced signal transduction, cytokine production, and proliferation was normal in [[PTPN3]] phosphatase-negative mice. This was observed using both quiescent T cells and recently stimulated T cells where expression of [[PTPN3]] is substantially up-regulated. We conclude, therefore, that the phosphatase activity of [[PTPN3]] is dispensable for negative regulation of TCR signal transduction and T cell activation.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Cell Proliferation<br /> * Cells, Cultured<br /> * Cytokines<br /> * Lymphocyte Activation<br /> * Mice<br /> * Mice, Transgenic<br /> * Protein Tyrosine Phosphatase, Non-Receptor Type 3<br /> * Protein Tyrosine Phosphatases<br /> * Receptors, Antigen, T-Cell<br /> * Signal Transduction<br /> * T-Lymphocytes<br /> * Up-Regulation<br /> <br /> |full-text-url=https://sci-hub.do/10.4049/jimmunol.178.6.3680<br /> }}</div>

OdysseusBot