https://transhumanist.ru/index.php?action=history&feed=atom&title=PRRX1 2026-06-27T09:24:18Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PRRX1&diff=4773&oldid=prev 2021-04-29T19:34:18Z

<p>Новая страница: «Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) [PMX1] ==Publications== {{medline-entry |title=A SIRT1...»</p> <p><b>Новая страница</b></p><div>Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) [PMX1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A [[SIRT1]]-centered circuitry regulates breast cancer stemness and metastasis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30038266<br /> |abstract=Cancer stem cell (CSC)-dictated intratumor heterogeneity accounts for the majority of drug-resistance and distant metastases of breast cancers. Here, we identify a [[SIRT1]]-[[PRRX1]]-[[KLF4]]-ALDH1 circuitry, which couples CSCs, chemo-resistance, metastasis and aging. Pro-longevity protein [[SIRT1]] deacetylates and stabilizes the epithelial-to-mesenchymal-transition (EMT) inducer [[PRRX1]], which inhibits the transcription of core stemness factor [[KLF4]]. Loss of [[SIRT1]] destabilizes [[PRRX1]], disinhibits [[KLF4]], and activates the transcription of ALDH1, which induces and functionally marks CSCs, resulting in chemo-resistance and metastatic relapse. Clinically, the level of [[PRRX1]] is positively linked to [[SIRT1]], whereas [[KLF4]] is reversely correlated. Importantly, [[KLF4]] inhibitor Kenpaullone sensitizes breast cancer cells and xenograft tumors to Paclitaxel and improves therapeutic effects. Our findings delineate a [[SIRT1]]-centered circuitry that regulates CSC origination, and targeting this pathway might be a promising therapeutic strategy.<br /> |mesh-terms=* Aging<br /> * Aldehyde Dehydrogenase 1 Family<br /> * Animals<br /> * Breast Neoplasms<br /> * Cell Line, Tumor<br /> * Drug Resistance, Neoplasm<br /> * Female<br /> * Gene Expression Regulation, Neoplastic<br /> * Homeodomain Proteins<br /> * Humans<br /> * Isoenzymes<br /> * Kruppel-Like Transcription Factors<br /> * Mice<br /> * Mice, Nude<br /> * Neoplasm Invasiveness<br /> * Neoplastic Stem Cells<br /> * Retinal Dehydrogenase<br /> * Signal Transduction<br /> * Sirtuin 1<br /> * Xenograft Model Antitumor Assays<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283862<br /> }}</div>

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