https://transhumanist.ru/index.php?action=history&feed=atom&title=PROS1 2026-08-08T20:10:33Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PROS1&diff=5234&oldid=prev 2021-05-12T13:35:19Z

<p>Новая страница: «Vitamin K-dependent protein S precursor [PROS] ==Publications== {{medline-entry |title=<a href="/PROC" title="PROC">PROC</a>, <a href="/PROC" title="PROC">PROC</a>R and <a href="/PROS1" title="PROS1">PROS1</a> polymorphisms, plasma anticoagulant phe...»</p> <p><b>Новая страница</b></p><div>Vitamin K-dependent protein S precursor [PROS]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[PROC]], [[PROC]]R and [[PROS1]] polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18680534<br /> |abstract=Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders. Using a tagSNP approach, and data from the Cardiovascular Health Study (CHS), we assessed associations of common polymorphisms of [[PROC]], [[PROS1]] and [[PROC]]R with: (i) plasma protein C, soluble protein C endothelial receptor (sEPCR) and protein S levels measured in a subsample of 336 participants at study entry; and (ii) risk of incident clinical outcomes [coronary heart disease (CHD), stroke, and mortality] in 4547 participants during follow-up. Secondarily, we explored associations between plasma protein C, protein S and sEPCR levels and other candidate genes involved in thrombosis, inflammation, and aging. The [[PROC]]R Ser219Gly polymorphism (rs867186) was strongly associated with higher sEPCR levels, explaining 75% of the phenotypic variation. The [[PROC]]R Ser219Gly variant was also associated with higher levels of circulating protein C antigen. An [[IL10]] polymorphism was associated with higher free protein S levels. The minor alleles of [[PROC]] rs2069901 and [[PROS1]] rs4857343 were weakly associated with lower protein C and free protein S levels, respectively. There was no association between [[PROC]]R Ser219Gly and risk of CHD, stroke, or mortality. The minor allele of another common [[PROC]]R tagSNP, rs2069948, was associated with lymphoid [[PROC]]R mRNA expression and with increased risk of incident stroke and all-cause mortality, and decreased healthy survival during follow-up. A common [[PROC]]R variant may be associated with decreased healthy survival in older adults. Additional studies are warranted to establish the role of [[PROC]]R variants in ischemic and aging-related disorders.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Antigens, CD<br /> * Blood Coagulation Factor Inhibitors<br /> * Cardiovascular Diseases<br /> * Coronary Disease<br /> * Endothelial Protein C Receptor<br /> * Female<br /> * Humans<br /> * Inflammation<br /> * Male<br /> * Middle Aged<br /> * Mortality<br /> * Polymorphism, Genetic<br /> * Protein C<br /> * Protein S<br /> * Receptors, Cell Surface<br /> * Risk<br /> * Stroke<br /> * Thrombosis<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856703<br /> }}</div>

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