https://transhumanist.ru/index.php?action=history&feed=atom&title=PPP2R3CPPP2R3C - История изменений2026-04-12T19:09:44ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=PPP2R3C&diff=4169&oldid=prevOdysseusBot: Новая страница: «Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) [C14orf...»2021-04-29T19:04:11Z<p>Новая страница: «Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) [C14orf...»</p>
<p><b>Новая страница</b></p><div>Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) [C14orf10] [G5PR]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30637918<br />
|abstract=We analyzed the small RNA transcriptome from 5-month-old, 24-month-old, and 36-month-old mouse liver and found 56 miRNAs that changed their expression profile with age. Among these is a cluster of 18 miRNAs that are upregulated between 50- and 1,000-fold at 24 and 36 months of age. This cluster is located in a 60-kb region of the X-chromosome that is devoid of other coding sequences and is part of a lamin-associated domain. Potential targets of the miRNAs in the cluster suggest they may regulate several pathways altered in aging, including the PI3K-Akt pathway. Total transcriptome analyses indicate that expression of several potential genes in the PI3K-Akt pathway that may be targeted by the mir-465 family (mmu-mir-465a, mmu-mir-465b, and mmu-mir-465c) is downregulated with age. Transfection of the liver cell line AML12 with mir-465 family members leads to a reduction of three of these potential targets at the mRNA level: a 40% reduction of the growth hormone receptor ([[GHR]]), and a 25% reduction in Kitl and [[PPP2R3C]]. Further investigation of the [[GHR]] 3'UTR revealed that the mir-465 family directly targets the [[GHR]] mRNA. Cells transfected with mir-465 showed a reduction of [[JAK2]] and STAT5 phosphorylation upon growth hormone (GH) stimulation, resulting in a reduction in insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein 3 expression. With age, GH signaling falls and there is a reduction in circulating IGF-1. Our data suggest that an increase in expression of the mir-465 family with age may contribute to the reduction in the GH signaling.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Growth Hormone<br />
* HEK293 Cells<br />
* High-Throughput Nucleotide Sequencing<br />
* Humans<br />
* Liver<br />
* Male<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* MicroRNAs<br />
* Signal Transduction<br />
* Up-Regulation<br />
|keywords=* aging<br />
* growth hormone receptor<br />
* growth hormone signaling<br />
* liver<br />
* miRNAs<br />
* mouse<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413667<br />
}}</div>OdysseusBot