https://transhumanist.ru/index.php?action=history&feed=atom&title=PPP2R2B 2026-06-10T01:01:05Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PPP2R2B&diff=4368&oldid=prev 2021-04-29T19:14:34Z

<p>Новая страница: «Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subuni...»</p> <p><b>Новая страница</b></p><div>Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Germline genetics of the p53 pathway affect longevity in a gender specific manner.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24654968<br /> |abstract=Aging is thought to occur through the accumulation of molecular and cellular damage. A key regulator of the cell&#039;s stress response is p53. In mice, the activity of p53 associates with lifespan. We were therefore interested whether SNPs in members of the p53-pathway are associated with longevity in humans. We genotyped the following SNPs: p53 - rs1042522 (Arg72Pro), [[MDM2]] - rs2279744 (SNP309), [[MDM4]] - rs4245739 (SNP34091), rs1563828 (SNP31826), [[PPP2R2B]] (rs319217) in 155 long-lived individuals (LLIs) who died at the age of 91 and over and in 171 ethnically-matched control subjects. Kaplan-Meier survival curves and log-Rank-test were used to determine the mean and median survival times. In female LLIs, the Pro-allele of rs1042522 (Arg72Pro) and the G-allele of rs2279744 (SNP309) were significantly associated with an increased survival time (P=0.026, P&lt;0.001, respectively, log-Rank-test). In contrast, there was no difference regarding the survival time in male LLIs (rs1042522: P=0.58, rs2279744: P=0.503, log-Rank-test). There was no difference regarding the average age of death for the genotypes of the respective SNPs in the [[MDM4]] gene (rs1563828: P=0.99; rs4245739: P=0.179, respectively). Here we show for the first time that the G-allele of rs2279744 (SNP309) is associated with increased lifespan. Importantly, this effect is gender-specific. Our data support the hypothesis that genetic variants that are associated with lower activity of p53--and therefore increased tumor risk--are associated with prolonged lifespan in a gender-specific manner.<br /> |mesh-terms=* Age Factors<br /> * Aged, 80 and over<br /> * Case-Control Studies<br /> * Cell Cycle Proteins<br /> * Female<br /> * Gene Frequency<br /> * Genotype<br /> * Humans<br /> * Kaplan-Meier Estimate<br /> * Longevity<br /> * Male<br /> * Nerve Tissue Proteins<br /> * Nuclear Proteins<br /> * Phenotype<br /> * Polymorphism, Single Nucleotide<br /> * Protein Phosphatase 2<br /> * Proto-Oncogene Proteins<br /> * Proto-Oncogene Proteins c-mdm2<br /> * Sex Factors<br /> * Signal Transduction<br /> * Time Factors<br /> * Tumor Suppressor Protein p53<br /> <br /> |full-text-url=https://sci-hub.do/10.2174/1874609807666140321150751<br /> }}</div>

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