https://transhumanist.ru/index.php?action=history&feed=atom&title=PPARD 2026-06-11T12:12:23Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PPARD&diff=4474&oldid=prev 2021-04-29T19:19:54Z

<p>Новая страница: «Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxiso...»</p> <p><b>Новая страница</b></p><div>Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) [NR1C2] [PPARB]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[PPARD]] 294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between [[PPARD]] 294T/C polymorphism and serum lipid profiles.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25873088<br /> |abstract=The 294T/C polymorphism in the peroxisome proliferator-activated receptor delta ([[PPARD]]) gene is associated with hyperlipidemia in several younger populations, but results are still inconsistence across ethnic groups and its possible impact on the lipid profiles of long-lived individuals remains unexploited. Here, we aimed to evaluate the possible correlation between [[PPARD]] 294T/C and serum lipid levels in a long-lived population in Bama, a region known for longevity situated in Guangxi, China. Genotyping of [[PPARD]] 294T/C polymorphism was conducted in 505 long-lived inhabitants (aged 90 and above, long-lived group, LG) and 468 healthy controls (aged 60-75, non-long-lived group, non-LG) recruited from Bama area. No difference in allelic and genotypic frequencies was found between the two groups (P&gt;0.05). However, C-allele and C-genotype (TC and CC) were significantly more frequent in the females of non-LG than were LG after sex stratification. CC carriers exhibited higher LDL-C level in LG (P&lt;0.05) but lower TC, [[TG]] and LDL-C in non-LG (P&lt;0.05 for each) than TT carriers; C allele carriers (TC/CC) in LG exhibited higher TC, [[TG]], and LDL-C levels as compared with the same genotype and the same lipid parameter in non-LG (P&lt;0.05 for each). LDL-C in LG was correlated with genotypes while TC, [[TG]], and LDL-C in non-LG were correlated with genotypes (P&lt;0.05-0.001). Our results suggest that there were different impact patterns of [[PPARD]] 294T/C polymorphism on lipid profiles between long-lived cohort and average population in Bama area and this may be one of the genetic bases of its longevity.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Asian Continental Ancestry Group<br /> * Case-Control Studies<br /> * China<br /> * Cholesterol<br /> * Cholesterol, HDL<br /> * Cholesterol, LDL<br /> * Female<br /> * Genetic Association Studies<br /> * Humans<br /> * Lipids<br /> * Longevity<br /> * Male<br /> * Middle Aged<br /> * PPAR delta<br /> * Polymorphism, Single Nucleotide<br /> * Triglycerides<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356147<br /> }}<br /> {{medline-entry<br /> |title=[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group].<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25826986<br /> |abstract=Genotype and allele frequencies of uncoupling proteins 2 and 3 genes ([[UCP2]] and [[UCP3]]) and peroxisome proliferator-activated receptors genes ([[PPARA]], [[PPARD]] and [[PPARG]]) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included [[UCP2]] (Ala55Val), [[UCP3]] (C-55T), [[PPARA]] (G/C), [[PPARD]] ( 294T/C), and [[PPARG]] (Pro12Ala). The G allele and the G/G genotype ([[PPARA]]) were overrepresented in the group of survivors and C/C ([[UCP3]]) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster. Feasible protective effects of [[PPARA]] gene allele G and C allele of [[UCP2]] genes are briefly discussed.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Case-Control Studies<br /> * Cities<br /> * Data Interpretation, Statistical<br /> * Female<br /> * Gene Frequency<br /> * Genotype<br /> * Humans<br /> * Ion Channels<br /> * Longevity<br /> * Male<br /> * Malnutrition<br /> * Mitochondrial Proteins<br /> * PPAR alpha<br /> * PPAR delta<br /> * PPAR gamma<br /> * Polymorphism, Single Nucleotide<br /> * Russia<br /> * Survivors<br /> * Uncoupling Protein 2<br /> * Uncoupling Protein 3<br /> * World War II<br /> <br /> <br /> }}</div>

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