https://transhumanist.ru/index.php?action=history&feed=atom&title=PCDH10 2026-04-08T15:48:20Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PCDH10&diff=4330&oldid=prev 2021-04-29T19:12:41Z

<p>Новая страница: «Protocadherin-10 precursor [KIAA1400] ==Publications== {{medline-entry |title=Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Ident...»</p> <p><b>Новая страница</b></p><div>Protocadherin-10 precursor [KIAA1400]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27878761<br /> |abstract=The human sense of smell decreases with age, and a poor sense of smell are among the most important prodromal symptoms of several neurodegenerative diseases. Recent evidence further suggests a racial difference in the sense of smell among U.S. older adults. However, no genome-wide association study (GWAS) on the sense of smell has been conducted in African-Americans (AAs). We performed the first genome-wide meta-analysis of the sense of smell among 1979 AAs and 6582 European-Americans (EAs) from three U.S. aging cohorts. In the AA population, we identified nine novel regions (KLF4-[[ACTL7B]], [[RAPGEF2]]-[[FSTL5]], [[TCF4]]-LOC100505474, [[PCDH10]], KIAA1751, [[MYO5B]], MIR320B1-[[CD2]], [[NR5A2]]-[[LINC00862]], [[SALL1]]-C16orf97) that were associated with the sense of smell (P &lt; 5 × 10 ). Many of these regions have been previously linked to neuropsychiatric (schizophrenia or epilepsy) or neurodegenerative (Parkinson&#039;s or Alzheimer&#039;s disease) diseases associated with a decreased sense of smell. In the EA population, we identified two novel loci in or near [[RASGRP1]] and ANXA2P3 associated with sense of smell. In conclusion, this study identified several ancestry-specific loci that are associated with the sense of smell in older adults. While these findings need independent confirmation, they may lead to novel insights into the biology of the sense of smell in older adults and its relationships to neuropsychological and neurodegenerative diseases.<br /> |mesh-terms=* African Americans<br /> * Aged<br /> * Aging<br /> * European Continental Ancestry Group<br /> * Female<br /> * Genetic Predisposition to Disease<br /> * Genome-Wide Association Study<br /> * Genotype<br /> * Humans<br /> * Male<br /> * Polymorphism, Single Nucleotide<br /> * Risk<br /> * Smell<br /> * United States<br /> |keywords=* African-American<br /> * GWAS<br /> * The sense of smell<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441979<br /> }}<br /> {{medline-entry<br /> |title=[[PCDH10]], a novel p53 transcriptional target in regulating cell migration.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25590240<br /> |abstract=Cell cycle arrest, senescence and apoptosis are commonly regarded as the major tumor suppression mechanisms of p53. However, accumulating evidence indicates that loss of these canonical functions is not sufficient for tumor formation, highlighting the complexity of p53-mediated tumor suppression. [[PCDH10]] belongs to a proto cadherin protein family and is a potential tumor suppressor protein as the dysregulation of [[PCDH10]] gene frequently existed in multiple human tumors. Here, we found that [[PCDH10]] is a transcriptional target of p53 and that the levels of [[PCDH10]] expression can be induced by wild type p53 but not mutant p53 in a number of human cancer cell lines. Moreover, we identified a p53 consensus binding site located in the [[PCDH10]] promoter region that is responsive to p53 regulation. Although upregulation of [[PCDH10]] has no obvious effect on growth arrest or apoptosis in human cells, [[PCDH10]] exhibits inhibitory roles in cancer cell motility and cell migration. These results suggest an important role of p53 in regulating tumor cell migration through activating [[PCDH10]] expression and support the notion that non-canonical activities of p53 may contribute to its tumor suppressor function in vivo.<br /> |mesh-terms=* Animals<br /> * Base Sequence<br /> * Cadherins<br /> * Cell Line<br /> * Cell Movement<br /> * Humans<br /> * Lymphoma, B-Cell<br /> * Mice<br /> * Molecular Sequence Data<br /> * RNA, Messenger<br /> * Transcription, Genetic<br /> * Tumor Suppressor Protein p53<br /> |keywords=* PCDH10<br /> * apoptosis and cell migration<br /> * cell cycle arrest<br /> * p53<br /> * senescence<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615063<br /> }}</div>

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