https://transhumanist.ru/index.php?action=history&feed=atom&title=PARL 2026-11-08T23:41:55Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PARL&diff=5545&oldid=prev 2021-05-12T13:49:08Z

<p>Новая страница: «Presenilins-associated rhomboid-like protein, mitochondrial precursor (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Contains: P-beta (Pbet...»</p> <p><b>Новая страница</b></p><div>Presenilins-associated rhomboid-like protein, mitochondrial precursor (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Contains: P-beta (Pbeta)] [PSARL] [PRO2207]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease [[PARL]].<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20444421<br /> |abstract=Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 ([[PARL]] ortholog) maintains the function and lifecycle of mitochondria. We examined whether variation in [[PARL]] protein content is associated with mitochondrial abnormalities and insulin resistance. [[PARL]] mRNA and mitochondrial mass were both reduced in elderly subjects and in subjects with T2DM. Muscle knockdown of [[PARL]] in mice resulted in malformed mitochondrial cristae, lower mitochondrial content, decreased PGC1alpha protein levels, and impaired insulin signaling. Suppression of [[PARL]] protein in healthy myotubes lowered mitochondrial mass and insulin-stimulated glycogen synthesis and increased reactive oxygen species production. We propose that lower [[PARL]] expression may contribute to the mitochondrial abnormalities seen in aging and T2DM.<br /> |mesh-terms=* Adolescent<br /> * Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Animals<br /> * Cells, Cultured<br /> * Diabetes Mellitus, Type 2<br /> * Glycogen<br /> * Humans<br /> * Insulin<br /> * Metalloproteases<br /> * Mice<br /> * Mice, Knockout<br /> * Middle Aged<br /> * Mitochondria<br /> * Mitochondrial Proteins<br /> * Muscle, Skeletal<br /> * Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha<br /> * Reactive Oxygen Species<br /> * Signal Transduction<br /> * Trans-Activators<br /> * Transcription Factors<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835349<br /> }}</div>

OdysseusBot