https://transhumanist.ru/index.php?action=history&feed=atom&title=PAK2 2026-04-09T07:11:13Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=PAK2&diff=4795&oldid=prev 2021-04-29T19:35:19Z

<p>Новая страница: «Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Contains: PAK-2p27 (p27); PAK-2p34...»</p> <p><b>Новая страница</b></p><div>Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Contains: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26794818<br /> |abstract=Tocotrienols have been known for their antioxidant properties besides their roles in cellular signalling, gene expression, immune response and apoptosis. This study aimed to determine the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing cellular senescence of human diploid fibroblasts (HDFs) by targeting the genes in senescence-associated signalling pathways. Real time quantitative PCR (qRT-PCR) was utilized to evaluate the expression of genes involved in these pathways. Our findings showed that [[SOD1]] and [[CCS]]-1 were significantly down-regulated in pre-senescent cells while [[CCS]]-1 and [[PRDX6]] were up-regulated in senescent cells (p&lt;0.05). Treatment with TRF significantly down-regulated [[SOD1]] in pre-senescent and senescent HDFs, up-regulated [[SOD2]] in senescent cells, [[CAT]] in young HDFs, [[GPX1]] in young and pre-senescent HDFs, and [[CCS]]-1 in young, pre-senescent and senescent HDFs (p&lt;0.05). TRF treatment also caused up-regulation of FOXO3A in all age groups of cells (p&lt;0.05). The expression of [[TP53]], [[PAK2]] and [[[[CDKN2A]]]] was significantly increased in senescent HDFs and treatment with TRF significantly down-regulated [[TP53]] in senescent cells (p&lt;0.05). [[MAPK14]] was significantly up-regulated (p&lt;0.05) in senescent HDFs while no changes was observed on the expression of [[JUN]]. TRF treatment, however, down-regulated [[MAPK14]] in young and senescent cells and up-regulated [[JUN]] in young and pre-senescent HDFs (p&lt;0.05). TRF modulated the expression of genes involved in senescence-associated signalling pathways during replicative senescence of HDFs.<br /> |mesh-terms=* Antioxidants<br /> * Cell Differentiation<br /> * Cell Proliferation<br /> * Cells, Cultured<br /> * Cellular Senescence<br /> * DNA Damage<br /> * Diploidy<br /> * Down-Regulation<br /> * Fibroblasts<br /> * Genetic Markers<br /> * Humans<br /> * Insulins<br /> * Real-Time Polymerase Chain Reaction<br /> * Signal Transduction<br /> * Tocotrienols<br /> * Up-Regulation<br /> |keywords=* Cellular senescence<br /> * Genes expression<br /> * Senescence-associated signalling pathways<br /> * Tocotrienol-rich fraction<br /> |full-text-url=https://sci-hub.do/10.7417/T.2015.1902<br /> }}</div>

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