https://transhumanist.ru/index.php?action=history&feed=atom&title=OPRM1 2026-07-07T00:39:00Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=OPRM1&diff=5650&oldid=prev 2021-05-12T13:53:46Z

<p>Новая страница: «Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) [MOR1] ==Publications== {{medline-entry |title=Variation at the...»</p> <p><b>Новая страница</b></p><div>Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) [MOR1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Variation at the mu-opioid receptor gene ([[OPRM1]]) influences attachment behavior in infant primates.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18378897<br /> |abstract=In a variety of species, development of attachment to a caregiver is crucial for infant survival and partly mediated by the endogenous opioids. Functional mu-opioid receptor gene polymorphisms are present in humans ([[OPRM1]] A118G) and rhesus macaques ([[OPRM1]] C77G). We hypothesized that rhesus infants carrying a gain-of-function [[OPRM1]] 77G allele would experience increased reward during maternal contact and would, therefore, display increased measures of attachment. We collected behavioral data from rhesus macaques (n = 97) during early infancy and at 6 months of age, across four cycles of maternal separation (4 days) and reunion (3 days). Animals were genotyped for the [[OPRM1]] C77G polymorphism, and the effects of this allele on attachment-related behaviors were analyzed. Infants carrying the G allele exhibited higher levels of attachment behavior during early infancy. During prolonged periods of maternal separation, although infant macaques homozygous for the C allele exhibited decreases in their levels of distress vocalization with repeated separation, this response persisted in G allele carriers. The [[OPRM1]] 77G allele also affected social preference during reunion. C/G infants spent increasing amounts of time in social contact with their mothers as a function of repeated separation and were less likely to interact with other individuals in the social group, a pattern not observed among infants with the C/C genotype. These findings suggest a role for [[OPRM1]] variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Behavior, Animal<br /> * Female<br /> * Genotype<br /> * Humans<br /> * Macaca mulatta<br /> * Male<br /> * Models, Animal<br /> * Mothers<br /> * Object Attachment<br /> * Polymorphism, Genetic<br /> * Receptors, Opioid, mu<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278187<br /> }}</div>

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