https://transhumanist.ru/index.php?action=history&feed=atom&title=OOEPOOEP - История изменений2026-06-17T23:29:24ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=OOEP&diff=4313&oldid=prevOdysseusBot: Новая страница: «Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19) [C6orf156] [KHDC2] [OEP19] ==Publica...»2021-04-29T19:11:35Z<p>Новая страница: «Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19) [C6orf156] [KHDC2] [OEP19] ==Publica...»</p>
<p><b>Новая страница</b></p><div>Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19) [C6orf156] [KHDC2] [OEP19]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Maternal gene [i]Ooep[/i] may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29955025<br />
|abstract=DNA damage in oocytes can cause infertility and birth defects. DNA double-strand breaks (DSBs) are highly deleterious and can substantially impair genome integrity. Homologous recombination ([[HR]])-mediated DNA DSB repair plays dominant roles in safeguarding oocyte quantity and quality. However, little is known regarding the key players of the [[HR]] repair pathway in oocytes. Here, we identified oocyte-specific gene [i]Ooep[/i] as a novel key component of the [[HR]] repair pathway in mouse oocytes. [[OOEP]] was required for efficient ataxia telangiectasia mutated (ATM) kinase activation and Rad51 recombinase(RAD51)focal accumulation at DNA DSBs. [i]Ooep[/i] null oocytes were defective in DNA DSB repair and prone to apoptosis upon exogenous DNA damage insults. Moreover, [i]Ooep[/i] null oocytes exhibited delayed meiotic maturation. Therefore, [[OOEP]] played roles in preserving oocyte quantity and quality by maintaining genome stability. [i]Ooep[/i] expression decreased with the advance of maternal age, suggesting its involvement in maternal aging.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* DNA Breaks, Double-Stranded<br />
* DNA Repair<br />
* Female<br />
* Meiosis<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Oocytes<br />
* RNA-Binding Proteins<br />
* Recombination, Genetic<br />
|keywords=* ATM<br />
* DNA double-strand break repair<br />
* Homologous recombination<br />
* Ooep<br />
* RAD51<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085769<br />
}}</div>OdysseusBot