https://transhumanist.ru/index.php?action=history&feed=atom&title=OLIG1 2026-04-07T23:15:55Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=OLIG1&diff=5235&oldid=prev 2021-05-12T13:35:22Z

<p>Новая страница: «Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21) [BHLHB6]...»</p> <p><b>Новая страница</b></p><div>Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21) [BHLHB6] [BHLHE21]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/14989603<br /> |abstract=Recent in situ hybridization studies showed that mRNA levels of [[OLIG1]] and [[OLIG2]] transcription factors are elevated in oligodendrogliomas. We raised polyclonal antibodies against a synthetic peptide homologous to the human transcription factor Olig1 and studied by immunohistochemistry the expression of Olig1 in 84 brain tumors and in non-neoplastic brain tissues. All oligodendrogliomas, oligoastrocytomas, and dysembryoplastic neuroepithelial tumors showed moderate to strong intranuclear immunoreactivity in cells morphologically identified as oligodendrocytes. In addition, some astrocytomas showed a slight to moderate intranuclear immunoreactivity. None of the other neuroepithelial and non-neuroepithelial tumors showed nuclear immunoreactivity. Double immunostaining of oligodendrogliomas, oligoastrocytomas, and glioblastoma multiforme (GBM) using antibodies against Olig1 and [[GFAP]] showed the presence of 3 different cell populations: 1) immunopositive for Olig1 and immunonegative for [[GFAP]], histologically identified as oligodendrocytes; 2) immunopositive only for [[GFAP]], histologically identified as astrocytes; and 3) immunonegative for both antibodies (&quot;null cells&quot;), histologically observed as a population of cells usually with round nuclei and a small amount of cytoplasm. The use of double immunostaining facilitated the distinction among these 3 different tumors. In summary, the use of immunohistochemistry using Olig1 antibodies alone or in combination with anti-[[GFAP]] antibody, which can be performed in the routine diagnostic setting, may help in the diagnosis of neuroepithelial tumors.<br /> |mesh-terms=* Adolescent<br /> * Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Astrocytoma<br /> * Basic Helix-Loop-Helix Transcription Factors<br /> * Blotting, Western<br /> * Brain Neoplasms<br /> * Cell Count<br /> * Child<br /> * Child, Preschool<br /> * DNA-Binding Proteins<br /> * Ependymoma<br /> * Glial Fibrillary Acidic Protein<br /> * Humans<br /> * Immunohistochemistry<br /> * Middle Aged<br /> * Nerve Tissue Proteins<br /> * Oligodendroglioma<br /> <br /> |full-text-url=https://sci-hub.do/10.1093/jnen/63.2.170<br /> }}</div>

OdysseusBot