https://transhumanist.ru/index.php?action=history&feed=atom&title=NRSN2NRSN2 - История изменений2026-04-09T12:33:53ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=NRSN2&diff=4366&oldid=prevOdysseusBot: Новая страница: «Neurensin-2 [C20orf98] ==Publications== {{medline-entry |title=Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway i...»2021-04-29T19:14:29Z<p>Новая страница: «Neurensin-2 [C20orf98] ==Publications== {{medline-entry |title=Down-Regulated <a href="/NRSN2" title="NRSN2">NRSN2</a> Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway i...»</p>
<p><b>Новая страница</b></p><div>Neurensin-2 [C20orf98]<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=Down-Regulated [[NRSN2]] Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26055238<br />
|abstract=Neurensin-2 ([[NRSN2]]) is a neuronal membrane protein; previous reports indicated that it might function as a tumor suppressor in hepatocellular carcinoma (HCC). However, its biological functions and associated mechanisms remain unknown. In the current study, we aimed to investigate the biological functions and possible mechanisms of neurensin-2. The mRNA and protein level of [[NRSN2]] in HCC has tissues and cell lines were detected by quantitative real-time PCR, immunohistochemistry staning and western blot. Overexpressing and silencing the level of [[NRSN2]] in HCC cell lines were used to investigate the role of [[NRSN2]] in HCC. [[CCK]]-8 assays, SA-β gel staining, Annexin V/PI staining, quantitative real-time PCR and western blot were employed to explore the role and mechanisms of HCC. [[NRSN2]] was more commonly down-regulated HCC tissues compared with adjacent tissues, and the expression pattern of [[NRSN2]] was not only closely correlated with tumor size and TNM stage but also negatively correlated with patient prognosis. Both loss and gain function assays revealed that [[NRSN2]] inhibits cancer cell proliferation and promotes cancer cell senescence and apoptosis. We further found that [[NRSN2]] might regulate PI3K/AKT signaling and p53/p21 pathway to exert its role in HCC cell proliferation, senescence and apoptosis. Our study validates the suppressive role of [[NRSN2]] in both clinicopathologic and biological aspects in HCC tumorigenesis.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aged<br />
* Biopsy, Needle<br />
* Blotting, Western<br />
* Carcinoma, Hepatocellular<br />
* Cell Proliferation<br />
* Cell Survival<br />
* Cellular Senescence<br />
* Chi-Square Distribution<br />
* Down-Regulation<br />
* Gene Expression Regulation, Neoplastic<br />
* Humans<br />
* Immunohistochemistry<br />
* Liver Neoplasms<br />
* Membrane Proteins<br />
* Middle Aged<br />
* Phosphatidylinositol 3-Kinases<br />
* Proto-Oncogene Proteins c-akt<br />
* RNA, Messenger<br />
* RNA, Small Interfering<br />
* Real-Time Polymerase Chain Reaction<br />
* Sampling Studies<br />
* Sensitivity and Specificity<br />
* Signal Transduction<br />
* TOR Serine-Threonine Kinases<br />
* Tumor Cells, Cultured<br />
* Young Adult<br />
|keywords=* Apoptosis<br />
* Cell proliferation<br />
* Cell senescence<br />
* Hepatocellular carcinoma<br />
* Neurensin-2<br />
* Patient prognosis<br />
|full-text-url=https://sci-hub.do/10.1007/s10620-015-3736-3<br />
}}</div>OdysseusBot