https://transhumanist.ru/index.php?action=history&feed=atom&title=NQO2NQO2 - История изменений2026-05-15T19:37:02ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=NQO2&diff=4446&oldid=prevOdysseusBot: Новая страница: «Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) [NMOR2...»2021-04-29T19:18:34Z<p>Новая страница: «Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) [NMOR2...»</p>
<p><b>Новая страница</b></p><div>Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) [NMOR2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase ([[NQO2]]).<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28346733<br />
|abstract=Dihydronicotinamide riboside:quinone oxidoreductase ([[NQO2]]) is an enzyme that performs reduction reactions involved in antioxidant defense. We hypothesized that [[NQO2]] hepatic drug clearance would develop in children over time, similar to [[NQO1]]. Using human liver cytosol (n = 117), the effects of age, sex, ethnicity, and weight on [[NQO2]] expression and activity were probed. No significant correlations were observed. Biochemical activity of [[NQO2]] was as high at birth as in adults (0.23 ± 0.04 nmol/min/mg protein, mean ± SEM, range 0-1.83). In contrast, modeled hepatic clearance through the [[NQO2]] pathway was up to 10% of adult levels at birth, reaching predicted adult levels (0.3 ± 0.03 L/h) at 14 years of age. Comparisons between [[NQO1]] and [[NQO2]] in the same livers showed that neither protein (P = 0.32) nor activity (P = 0.23) correlated, confirming both orthologs are independently regulated. Because hepatic clearance through [[NQO2]] does not mature until teenage years, compounds detoxified by this enzyme may be more deleterious in children.<br />
|mesh-terms=* Aging<br />
* Female<br />
* Humans<br />
* Liver<br />
* Male<br />
* NAD(P)H Dehydrogenase (Quinone)<br />
* Quinone Reductases<br />
|keywords=* antioxidants<br />
* drug metabolism<br />
* in vitro-in vivo extrapolation<br />
* pediatric<br />
* physiologically based pharmacokinetic modeling<br />
|full-text-url=https://sci-hub.do/10.1002/jbt.21921<br />
}}</div>OdysseusBot