https://transhumanist.ru/index.php?action=history&feed=atom&title=NPAS1 2026-06-28T00:29:20Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=NPAS1&diff=5702&oldid=prev 2021-05-12T13:56:02Z

<p>Новая страница: «Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member o...»</p> <p><b>Новая страница</b></p><div>Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) [BHLHE11] [MOP5] [PASD5]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Behavioral and regulatory abnormalities in mice deficient in the [[NPAS1]] and [[NPAS3]] transcription factors.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15347806<br /> |abstract=Laboratory mice bearing inactivating mutations in the genes encoding the [[NPAS1]] and [[NPAS3]] transcription factors have been shown to exhibit a spectrum of behavioral and neurochemical abnormalities. Behavioral abnormalities included diminished startle response, as measured by prepulse inhibition, and impaired social recognition. [[NPAS1]]/[[NPAS3]]-deficient mice also exhibited stereotypic darting behavior at weaning and increased locomotor activity. Immunohistochemical staining assays showed that the [[NPAS1]] and [[NPAS3]] proteins are expressed in inhibitory interneurons and that the viability and anatomical distribution of these neurons are unaffected by the absence of either transcription factor. Adult brain tissues from [[NPAS3]]- and [[NPAS1]]/[[NPAS3]]-deficient mice exhibited a distinct reduction in reelin, a large, secreted protein whose expression has been reported to be attenuated in the postmortem brain tissue of patients with schizophrenia. These observations raise the possibility that a regulatory program controlled in inhibitory interneurons by the [[NPAS1]] and [[NPAS3]] transcription factors may be either substantively or tangentially relevant to psychosis.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Basic Helix-Loop-Helix Transcription Factors<br /> * Behavior, Animal<br /> * Brain<br /> * Cell Adhesion Molecules, Neuronal<br /> * Extracellular Matrix Proteins<br /> * Gene Deletion<br /> * Gene Expression Profiling<br /> * Homozygote<br /> * Mice<br /> * Mice, Knockout<br /> * Nerve Tissue Proteins<br /> * Neurons<br /> * Serine Endopeptidases<br /> * Social Behavior<br /> * Transcription Factors<br /> * gamma-Aminobutyric Acid<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC518807<br /> }}</div>

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