https://transhumanist.ru/index.php?action=history&feed=atom&title=NOX5 2026-08-22T20:05:40Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=NOX5&diff=5611&oldid=prev 2021-05-12T13:52:07Z

<p>Новая страница: «NADPH oxidase 5 (EC 1.6.3.-) ==Publications== {{medline-entry |title=Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. |pubmed-url=http...»</p> <p><b>Новая страница</b></p><div>NADPH oxidase 5 (EC 1.6.3.-)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15820617<br /> |abstract=Oxidative damage is thought to play a key role in the aging of various organ systems. In this study, we have therefore analyzed mRNA expression of ROS-generating NADPH oxidases in the aging stomach. Gastric biopsies of hospitalized geriatric patients were analyzed for histology (Sidney classification), and real-time PCR was used to quantify mRNA expression of the superoxide-generating NADPH oxidases [[NOX1]], NOX2, and [[NOX5]]. We found that stomach biopsies of elderly patients expressed [[NOX5]] and NOX2 mRNA, but not [[NOX1]]. The mRNA expression of [[NOX5]] (a lymphocyte NADPH oxidase) neither depended on age nor on the results of the stomach histology. In contrast, mRNA expression of NOX2 (phagocyte NADPH oxidase) was a function of two variables. Increased NOX2 mRNA levels were observed in biopsies with signs of chronic inflammation (p=0.01). Interestingly, however, there was also an age-dependent increase in NOX2 mRNA levels (p=0.01). We conclude that in elderly patients the gastric mRNA expression of the ROS-generating enzyme NOX2 increases as a function of age, possibly contributing to stomach aging and gastric vulnerability of the elderly.<br /> |mesh-terms=* Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Biopsy<br /> * Chronic Disease<br /> * Female<br /> * Gastritis<br /> * Gene Expression<br /> * Humans<br /> * Male<br /> * Membrane Glycoproteins<br /> * Membrane Proteins<br /> * NADPH Oxidase 1<br /> * NADPH Oxidase 2<br /> * NADPH Oxidase 5<br /> * NADPH Oxidases<br /> * Polymerase Chain Reaction<br /> * RNA, Messenger<br /> * Reactive Oxygen Species<br /> * Severity of Illness Index<br /> * Stomach<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.exger.2005.01.007<br /> }}</div>

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